A Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma
| Status: | Recruiting |
|---|---|
| Conditions: | Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 6 - Any |
| Updated: | 2/7/2015 |
| Start Date: | August 2011 |
| End Date: | January 2017 |
| Contact: | Terri Lowe |
| Email: | clinicaltrials@seagen.com |
| Phone: | 866-333-7436 |
A Phase 2 Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL)
This is an open-label, multicenter, phase 2 clinical trial to evaluate the efficacy and
safety of brentuximab vedotin as a single agent in patients with CD30-positive non-Hodgkin
lymphoma (NHL) (Part A). The study will also evaluate the safety and efficacy of
brentuximab vedotin in combination with rituximab in patients with relapsed or refractory
diffuse large B-cell lymphoma (DLBCL) (Part B) as well as further evaluate correlation of
CD30 expression and response in DLBCL (Part C).
safety of brentuximab vedotin as a single agent in patients with CD30-positive non-Hodgkin
lymphoma (NHL) (Part A). The study will also evaluate the safety and efficacy of
brentuximab vedotin in combination with rituximab in patients with relapsed or refractory
diffuse large B-cell lymphoma (DLBCL) (Part B) as well as further evaluate correlation of
CD30 expression and response in DLBCL (Part C).
Inclusion Criteria:
- Histologically-confirmed NHL (DLBCL only for Parts B and C)
- Relapsed or refractory disease following at least 1 prior systemic therapy
- Measurable disease of at least 1.5 cm as documented by CT
- ECOG performance status less than or equal to 2
Exclusion Criteria:
- History of another primary invasive malignancy that has not been in remission for at
least 3 years
- Current diagnosis of systemic or cutaneous anaplastic large cell lymphoma or mycosis
fungoides
- B cell lymphoma previously treated with only single-agent rituximab (for patients
receiving brentuximab vedotin only) or corticosteroids as monotherapy
- Known cerebral/meningeal disease
We found this trial at
33
sites
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University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Northwestern University Northwestern is recognized both nationally and internationally for the quality of its educational...
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University of Chicago One of the world's premier academic and research institutions, the University of...
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Memorial Sloan-Kettering Cancer Center Memorial Sloan-Kettering Cancer Center — the world's oldest and largest private...
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Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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1721 East 19th Ave., Suite #200 & #300
Denver, Colorado 80218
Denver, Colorado 80218
720-754-4800
Colorado Blood Cancer Institute When patients come to the Colorado Blood Cancer Institute, the entire...
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1500 East Duarte Road
Duarte, California 91010
Duarte, California 91010
626-256-HOPE (4673)
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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9280 W. Sunset Road
Suite 100
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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Oxnard, California 93030
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660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Stanford University Cancer Institute The Stanford Cancer Institute (SCI) focuses the world-class expertise of more...
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