A Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma
| Status: | Recruiting |
|---|---|
| Conditions: | Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 6 - Any |
| Updated: | 2/7/2015 |
| Start Date: | August 2011 |
| End Date: | January 2017 |
| Contact: | Terri Lowe |
| Email: | clinicaltrials@seagen.com |
| Phone: | 866-333-7436 |
A Phase 2 Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL)
This is an open-label, multicenter, phase 2 clinical trial to evaluate the efficacy and
safety of brentuximab vedotin as a single agent in patients with CD30-positive non-Hodgkin
lymphoma (NHL) (Part A). The study will also evaluate the safety and efficacy of
brentuximab vedotin in combination with rituximab in patients with relapsed or refractory
diffuse large B-cell lymphoma (DLBCL) (Part B) as well as further evaluate correlation of
CD30 expression and response in DLBCL (Part C).
safety of brentuximab vedotin as a single agent in patients with CD30-positive non-Hodgkin
lymphoma (NHL) (Part A). The study will also evaluate the safety and efficacy of
brentuximab vedotin in combination with rituximab in patients with relapsed or refractory
diffuse large B-cell lymphoma (DLBCL) (Part B) as well as further evaluate correlation of
CD30 expression and response in DLBCL (Part C).
Inclusion Criteria:
- Histologically-confirmed NHL (DLBCL only for Parts B and C)
- Relapsed or refractory disease following at least 1 prior systemic therapy
- Measurable disease of at least 1.5 cm as documented by CT
- ECOG performance status less than or equal to 2
Exclusion Criteria:
- History of another primary invasive malignancy that has not been in remission for at
least 3 years
- Current diagnosis of systemic or cutaneous anaplastic large cell lymphoma or mycosis
fungoides
- B cell lymphoma previously treated with only single-agent rituximab (for patients
receiving brentuximab vedotin only) or corticosteroids as monotherapy
- Known cerebral/meningeal disease
We found this trial at
33
sites
1500 East Duarte Road
Duarte, California 91010
Duarte, California 91010
626-256-HOPE (4673)
City of Hope National Medical Center City of Hope is dedicated to making a difference...
Click here to add this to my saved trials
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
Click here to add this to my saved trials
Northwestern University Northwestern is recognized both nationally and internationally for the quality of its educational...
Click here to add this to my saved trials
University of Chicago One of the world's premier academic and research institutions, the University of...
Click here to add this to my saved trials
Memorial Sloan-Kettering Cancer Center Memorial Sloan-Kettering Cancer Center — the world's oldest and largest private...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
1721 East 19th Ave., Suite #200 & #300
Denver, Colorado 80218
Denver, Colorado 80218
720-754-4800
Colorado Blood Cancer Institute When patients come to the Colorado Blood Cancer Institute, the entire...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
Click here to add this to my saved trials
Click here to add this to my saved trials
9280 W. Sunset Road
Suite 100
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
Click here to add this to my saved trials
Click here to add this to my saved trials
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
Click here to add this to my saved trials
Click here to add this to my saved trials
Oxnard, California 93030
Click here to add this to my saved trials
Click here to add this to my saved trials
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Stanford University Cancer Institute The Stanford Cancer Institute (SCI) focuses the world-class expertise of more...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials