Effect of Oocyte Vitrification on Fertilization Rate, Embryo Quality and Development
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 21 - 37 |
| Updated: | 5/5/2014 |
| Start Date: | August 2011 |
| End Date: | October 2012 |
| Contact: | Eileen B. Davies |
| Email: | daviese@mainlinefertility.com |
| Phone: | 484-337-8955 |
A Study to Compare Vitrified/Warmed Oocytes vs. Fresh Sibling Oocytes Collected Following Controlled Ovarian Stimulation Using Follistim AQ and Ganirelix Acetate on Fertilization Rates, Zygote Quality, Embryo Quality and Embryo Development
Indications for oocyte (egg) vitrification (fast freezing) include the preservation of
reproductive competence of young cancer patients who need chemotherapy, pelvic radiation, or
surgical removal of ovaries for treatment. Furthermore, the ability to freeze oocytes allows
patients to reduce the number of embryos frozen, thereby circumventing the moral and ethical
dilemmas of having left-over embryos in cryostorage. In addition, oocyte cryopreservation
could allow women to delay childbearing if they want or need to. Until recently,
conventional cryopreservation protocols have remained too inefficient for practical
application in an infertility center. Very little is known about the effects of
vitrification on oocytes and subsequent embryo development, especially using the sibling
model (group of oocytes from the same cohort of ovarian follicles within patient). The
purpose of this study is to examine the effect of oocyte vitrification on fertilization
rates, embryo quality and development.
reproductive competence of young cancer patients who need chemotherapy, pelvic radiation, or
surgical removal of ovaries for treatment. Furthermore, the ability to freeze oocytes allows
patients to reduce the number of embryos frozen, thereby circumventing the moral and ethical
dilemmas of having left-over embryos in cryostorage. In addition, oocyte cryopreservation
could allow women to delay childbearing if they want or need to. Until recently,
conventional cryopreservation protocols have remained too inefficient for practical
application in an infertility center. Very little is known about the effects of
vitrification on oocytes and subsequent embryo development, especially using the sibling
model (group of oocytes from the same cohort of ovarian follicles within patient). The
purpose of this study is to examine the effect of oocyte vitrification on fertilization
rates, embryo quality and development.
Inclusion Criteria:
- healthy women ages 21-37 (inclusive)undergoing IVF in an attempt to achieve pregnancy
- Day 2-4 FSH < 10 IU/ml, LH <12 IU/ml, and E2 <50 pg/ml
- Antimullerian Hormone (AMH) >1.5
- Between 5 and 20 basal antral follicles on day 2-4 of the menstrual cycle
- BMI >18 and <32
Exclusion Criteria:
- Smokers
- Polycystic Ovarian Syndrome (PCO)
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