Lifestyle Interventions for Seniors With Apnea
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 60 - 75 |
| Updated: | 4/2/2016 |
| Start Date: | October 2010 |
| End Date: | July 2012 |
| Contact: | Devon A Dobrosielski, PhD |
| Email: | ddobros1@jhmi.edu |
| Phone: | 410-550-5596 |
Effects of Weight Loss Through Diet and Exercise on Sleep Apnea Severity and Cardiovascular Risk in Older Adults
The overall goal of this study is to determine the efficacy of a lifestyle intervention,
consisting of a weight loss diet and exercise on sleep apnea in older adults. The
investigators will conduct a 3-month intervention in men and women who are sedentary with
suspected sleep apnea. The investigators hypothesize that the intervention will lead to
marked improvements in sleep apnea severity and cardiovascular risk markers.
consisting of a weight loss diet and exercise on sleep apnea in older adults. The
investigators will conduct a 3-month intervention in men and women who are sedentary with
suspected sleep apnea. The investigators hypothesize that the intervention will lead to
marked improvements in sleep apnea severity and cardiovascular risk markers.
Frailty, a condition characterized by a decrease in physiological reserve and increased risk
for adverse health-related outcomes, is an increased risk of aging, especially in the
presence of co-morbid conditions. Sleep apnea is also highly prevalent with increasing age.
Both conditions share common pathologies, suggesting that sleep apnea may increase the risk
of developing or exacerbate the consequences of frailty. Lifestyle interventions as
strategies for treating sleep apnea and associated co-morbidities, thereby highlighting a
feasible approach by which to reduce the incidence or progression of frailty. The specific
aims of this study are to: 1) determine the effectiveness of a lifestyle intervention (LI),
consisting of a weight loss diet and supervised exercise, on reducing sleep apnea in older
adults, and 2) determine whether this intervention is effective at improving parameters that
are common to both sleep apnea and frailty, such as poor physical functional capacity and
body composition, impaired or abnormal cardiometabolic function and increased levels of
inflammation.
for adverse health-related outcomes, is an increased risk of aging, especially in the
presence of co-morbid conditions. Sleep apnea is also highly prevalent with increasing age.
Both conditions share common pathologies, suggesting that sleep apnea may increase the risk
of developing or exacerbate the consequences of frailty. Lifestyle interventions as
strategies for treating sleep apnea and associated co-morbidities, thereby highlighting a
feasible approach by which to reduce the incidence or progression of frailty. The specific
aims of this study are to: 1) determine the effectiveness of a lifestyle intervention (LI),
consisting of a weight loss diet and supervised exercise, on reducing sleep apnea in older
adults, and 2) determine whether this intervention is effective at improving parameters that
are common to both sleep apnea and frailty, such as poor physical functional capacity and
body composition, impaired or abnormal cardiometabolic function and increased levels of
inflammation.
Inclusion Criteria:
- aged 60-75
- BMI between 30-42
- Apnea-Hypopnea Index above 10 events per hour (verified at baseline testing)
Exclusion Criteria:
- currently following a weight loss diet
- history of substance abuse
- participating in moderate to vigorous activity most days of the week
- history of cardiovascular disease
- currently being treated for sleep apnea
- current cigarette smoking
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