Pharmacokinetics Study of Dapsone-Adapalene Fixed Combination Gel in Acne
| Status: | Completed |
|---|---|
| Conditions: | Acne, Acne, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | January 2013 |
| End Date: | June 2013 |
| Contact: | Allergan Inc. |
| Email: | clinicaltrials@allergan.com |
This study will investigate the pharmacokinetics, safety and tolerability of dapsone and
adapalene following topical administration of 2 formulations of dapsone/adapalene fixed
combination gel, dapsone 5% gel (ACZONE®), and adapalene 0.3% gel (Differin®) in subjects
with acne vulgaris.
Inclusion Criteria:
- Moderate acne on the face
- Willing to avoid swimming during the study
- Willing to avoid excessive sunlight and ultraviolet light (e.g., tanning beds)during
the study
- Willing to avoid moisturizers, sunscreens, cosmetics, and chemical peels during the
study
Exclusion Criteria:
- Severe cystic acne
- Use of topical or oral retinoids within 4 weeks
- Use of isotretinoin within 3 months
- Use of dapsone or adapalene within 3 months
- Anticipated need to engage in activities/exercise that would cause profuse sweating
- Donated blood or equivalent blood loss within 90 days
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