Neural Oscillations as Genetic and Functional Biomarkers in Normal and Disease States

There are several studies and hypotheses to be tested. This project includes a
cross-sectional study design measuring brain waves, clinical symptoms, cognitive and
functional ability, and genetic information in schizophrenic patients and normal controls.
Subjects are expected to do a brain wave recording (EEG/ERP), role-play test designed to
measure functionality and cognitive ability, and clinical symptom assessments. Expected
duration of subject participation will be approximately 8 hours (about 2 visits). Outcome
measures includes biomarkers, clinical symptoms and function, and genetic information.

Inclusion Criteria:

- Male and Female between ages 14-62 (clinical assessment and blood draw only above 62)

- Ability to give written assent (subjects who are below the age of 18)

- Ability to give written informed consent (age 18 or above)

- Sufficient understanding of the study and risks (ESC score 10 or above)

- Subjects above age 62 will not participate in brain electrical activity measurements
although they may still participate in clinical assessments and blood draw.

Exclusion Criteria:

- Inability to sign informed consent/assent

- Any major medical illness that may affect normal brain functioning. Examples of these
conditions include, but not limited to, stroke, repeated seizure, history of
significant head trauma, CNS infection or tumor, an other significant brain
neurological conditions.

- Significant alcohol or drug use (substance dependence within 6 months or substance
abuse within 1 month) other than nicotine or marijuana dependence.

- Woman who is pregnant (child bearing potential but not on contraceptive and missing
menstrual period; or by self-report; or by positive pregnancy test).

- Can not refrain from using alcohol and/or marijuana 24 hours or more& cigarette
smoking half and hour or more prior to experiments.