Value of 25 mcg Cortrosyn Stimulation Test
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | September 2011 |
| End Date: | January 2015 |
The Value of 25 mcg Cortrosyn Stimulation Test to Assess Adult HPA Axis
The diagnosis of secondary AI is vital to prevent catastrophic events in patients. An
optimal test should have a very low margin of error with high sensitivity and specificity,
be easy and safe to administer, and have distinct cut off values. Both 1 ug and 250 ug doses
have their limitations. Based on our experience over the past six years, we hypothesize that
25 ug ACTH stimulation test may eliminate some of the shortcomings of the LDST (1 ug) and
SDST (250 ug). This is supported by our preliminary data and the study by Oelkers et al,
which looked at ACTH levels following various doses of cortrosyn injections.
Therefore we propose a head to head comparison of 25 ug, 250 ug and 1 ug dose using ITT as
gold standard.
optimal test should have a very low margin of error with high sensitivity and specificity,
be easy and safe to administer, and have distinct cut off values. Both 1 ug and 250 ug doses
have their limitations. Based on our experience over the past six years, we hypothesize that
25 ug ACTH stimulation test may eliminate some of the shortcomings of the LDST (1 ug) and
SDST (250 ug). This is supported by our preliminary data and the study by Oelkers et al,
which looked at ACTH levels following various doses of cortrosyn injections.
Therefore we propose a head to head comparison of 25 ug, 250 ug and 1 ug dose using ITT as
gold standard.
Inclusion Criteria:
- hypothalamic-pituitary-adrenal disorders
Exclusion Criteria:
- under 18 or older than 65 years of age
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