Hematopoietic Stem Cell Transplantation in Patients With Antiphospholipid Syndrome

Antiphospholipid syndrome is disease believed to be due to immune cells, cells which
normally protect the body, but are now producing the protein which leads to abnormal
clotting in the body. This study is designed to examine whether treating patients with high
dose cyclophosphamide together with CAMPATH (drugs which reduce the function of the immune
system), followed by return of the previously collected stem cells will result in
improvement in the disease. Stem cells are undeveloped cells that have the capacity to grow
into mature blood cells, which normally circulate in the blood stream. The purpose of the
intense chemotherapy is to destroy the cells in the immune system which may be causing the
disease. The purpose of the stem cell infusion is to produce a normal immune system that
will no longer attack the body. The study purpose is to examine whether this treatment
will result in improvement in the disease. The drugs used in this study treatment are drugs
for commonly used for immune suppression.