Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Neurology, Orthopedic |
| Therapuetic Areas: | Neurology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 10 - 80 |
| Updated: | 7/28/2016 |
| Start Date: | May 2012 |
| End Date: | August 2016 |
Can Short Latency Afferent Inhibition Give us Clues to Better Dystonia Treatments?
This is a research study using transcranial magnetic stimulation (TMS) to investigate
interactions between the sensory system and the motor cortex in primary generalized dystonia
(DYT1 dystonia) subjects who undergo deep brain stimulation (DBS) surgery.
The sensory system is the body's sense organs - smell, sight, sound, etc. - and the motor
cortex is the part of your brain where nerve impulses control voluntary muscle activity.
interactions between the sensory system and the motor cortex in primary generalized dystonia
(DYT1 dystonia) subjects who undergo deep brain stimulation (DBS) surgery.
The sensory system is the body's sense organs - smell, sight, sound, etc. - and the motor
cortex is the part of your brain where nerve impulses control voluntary muscle activity.
The cause of DYT1 dystonia is not clear. DYT1 dystonia symptoms include abnormal posture or
repetitive twisting movements affecting one body part; in some patients, the entire body can
twist and contort painfully. Magnetic resonance imaging (MRI) studies are normally used to
evaluate changes in brain structure in DYT1 dystonia. Transcranial magnetic stimulation
(TMS) is a painless, non-invasive method to test how your brain conducts electrical messages
to the rest of your body, including your muscles.
If you are a DYT1 dystonia patient, then this study involves up to three visits. The first
visit (before DBS surgery) will last about 4 hours and the second and third visits (after
DBS surgery) will last about 4 hours as well. These visits will include a complete physical
and neurological exam, video recorded dystonia and mood rating scales, followed by
electromyography (EMG) and TMS sessions. Subjects who have already undergone DBS surgery may
participate in applicable visits based on the length of time since their DBS surgery.
If you are a control subject, this study involves one visit, about 4 hours long. This visit
will include TMS and EMG sessions.
repetitive twisting movements affecting one body part; in some patients, the entire body can
twist and contort painfully. Magnetic resonance imaging (MRI) studies are normally used to
evaluate changes in brain structure in DYT1 dystonia. Transcranial magnetic stimulation
(TMS) is a painless, non-invasive method to test how your brain conducts electrical messages
to the rest of your body, including your muscles.
If you are a DYT1 dystonia patient, then this study involves up to three visits. The first
visit (before DBS surgery) will last about 4 hours and the second and third visits (after
DBS surgery) will last about 4 hours as well. These visits will include a complete physical
and neurological exam, video recorded dystonia and mood rating scales, followed by
electromyography (EMG) and TMS sessions. Subjects who have already undergone DBS surgery may
participate in applicable visits based on the length of time since their DBS surgery.
If you are a control subject, this study involves one visit, about 4 hours long. This visit
will include TMS and EMG sessions.
INCLUSION CRITERIA:
- Between the ages of 10 and 80 years. (CONTROL SUBJECTS between 18-80 years)
- Diagnosis and genetic test results confirming diagnosis of DYT1 dystonia.
- Currently treated with medications and enrolled in evaluation process for DBS surgery
to confirm candidacy - OR -
- Previous DBS surgery
EXCLUSION CRITERIA:
- Implanted pacemaker, medication pump, vagal stimulator, Transcutaneous electrical
nerve stimulation (TENS) unit or ventriculoperitoneal shunt.
- Family or personal history of medication refractory epilepsy.
- Pregnancy: due to the frequent visits over a prolonged period and the lack of
Information on the safety of TMS during pregnancy, pregnant women will not be
eligible to participate in this study. Women of childbearing potential will be
eligible to participate, provided that they are using adequate contraception during
TMS treatments.
This study is accepting healthy volunteers, aged 18-80, as control subjects. Control
subjects will not undergo DBS surgery.
EXCLUSION CRITERIA (as it applies to healthy control subjects):
- Cannot have family history or personal history of medication refractory epilepsy
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