A Study of a New Asthma Medicine in Asthmatics Whose Asthma Worsens With Exercise
Status: | Completed |
---|---|
Conditions: | Asthma, Pulmonary |
Therapuetic Areas: | Pulmonary / Respiratory Diseases |
Healthy: | No |
Age Range: | Any |
Updated: | 2/4/2013 |
Start Date: | October 2011 |
End Date: | August 2012 |
Contact: | US GSK Clinical Trials Call Center |
Email: | GSKClinicalSupportHD@gsk.com |
Phone: | 877-379-3718 |
A Randomized, Double-Blind, Double-Dummy, Crossover Comparison of Fluticasone Furoate/Vilanterol 100/25 Mcg Once Daily Versus Fluticasone Propionate 250 Mcg Twice Daily in Asthmatic Adolescent and Adult Subjects With Exercise-Induced Bronchoconstriction
The primary objective of this study is to demonstrate that the combination of inhaled
fluticasone furoate/vilanterol (100 mcg/25 mcg) once daily provides superior protection
throughout the day against bronchoconstriction induced by exercise compared with fluticasone
propionate 250 mcg twice daily in adolescent and adult subjects aged 12 to 50 diagnosed with
persistent asthma.
Inclusion Criteria:
- Outpatient male or female 12 to 50 years of age
- Females of child-bearing potential must be willing to use birth control or commit to
abstinence during the study
- Diagnosis of persistent asthma for at least 6 months
- Best pre-bronchodilator FEV1 of at least 70%.
- Current use of a low- to moderate-dose inhaled corticosteroid
- Ability to withhold albuterol 6 hours prior to visits.
- Physically able to perform exercise testing on a treadmill when albuterol has been
withheld
Exclusion Criteria:
- Intermittent asthma, seasonal asthma, or exercise-induced asthma only
- Symptomatic allergic rhinitis and/or thrush
- Abnormal, clinically significant electrocardigraph
- Respiratory infection within 4 weeks of first visit leading to asthma medication
change or could affect subjects's asthma status or participation
- Asthma exacerbation within 12 weeks of first visit
- Respiratory diseases or other concurrent disease that would put subject at risk or
confound results interpretation
- Investigational medicines within 30 days of first visit or less than five half-lives
of medication in prior study
- Allergy to study drugs or study drug excipients
- Concomitant medications that could interact with study medications or affect the
course of asthma
- Tobacco use within last year and/or a 10 pack-years history
- Inability to comply with requirements of the study
- Affiliation with investigator's site (example: family member)
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