A Study of a New Asthma Medicine in Asthmatics Whose Asthma Worsens With Exercise

Inclusion Criteria:

- Outpatient male or female 12 to 50 years of age

- Females of child-bearing potential must be willing to use birth control or commit to
abstinence during the study

- Diagnosis of persistent asthma for at least 6 months

- Best pre-bronchodilator FEV1 of at least 70%.

- Current use of a low- to moderate-dose inhaled corticosteroid

- Ability to withhold albuterol 6 hours prior to visits.

- Physically able to perform exercise testing on a treadmill when albuterol has been
withheld

Exclusion Criteria:

- Intermittent asthma, seasonal asthma, or exercise-induced asthma only

- Symptomatic allergic rhinitis and/or thrush

- Abnormal, clinically significant electrocardigraph

- Respiratory infection within 4 weeks of first visit leading to asthma medication
change or could affect subjects's asthma status or participation

- Asthma exacerbation within 12 weeks of first visit

- Respiratory diseases or other concurrent disease that would put subject at risk or
confound results interpretation

- Investigational medicines within 30 days of first visit or less than five half-lives
of medication in prior study

- Allergy to study drugs or study drug excipients

- Concomitant medications that could interact with study medications or affect the
course of asthma

- Tobacco use within last year and/or a 10 pack-years history

- Inability to comply with requirements of the study

- Affiliation with investigator's site (example: family member)