Dose Finding Study for QAW039 in Asthma

Inclusion Criteria: - Physician diagnosis of asthma, as per the Global Initiative for
Asthma (GINA) (2009) guidelines, and currently prescribed Inhaled Corticosteroids (ICS)
therapy. - Patients with a pre-bronchodilator Forced Expiratory Volume in 1 second (FEV1)
value of 40% to 80% of individual predicted value. - Patients should be allergic or
atopic, as diagnosed historically or prior to entry into the study. - Patients who are
demonstrated to have reversible airway obstruction or airways hyper-reactivity or have
shown either of such responses in previous test(s) within the last year. - An Asthma
Control Questionnaire (ACQ) score ≥ 1.5 at randomization. Exclusion Criteria: - Pregnant
or nursing (lactating) women, where pregnancy is defined as the state of a female after
conception and until the termination of gestation, confirmed by a positive human chorionic
gonadotropin (hCG) laboratory test (> 5 mIU/mL). - Patients with serious co-morbidities
including uncontrolled diabetes (HbA1c≥8%), heart failure, cancer, neurodegenerative
diseases, rheumatoid arthritis and other autoimmune diseases, other lung diseases
including chronic bronchitis, chronic obstructive pulmonary diseases or emphysema or other
conditions characterized by eosinophilia and pulmonary symptoms (i.e. Churg-Strauss
syndrome, allergic bronchopulmonary aspergillosis, eosinophilic pneumonia, etc.). - Acute
illness other than asthma at the start of the study - History of life-threatening asthma,
including a history of significant hypercarbia (pCO2>45mmHg), prior intubation,
respiratory arrest, or seizures as a result of asthma. - Patients who have had a
respiratory tract infection within 4 weeks of the screening visit. Patients who develop a
respiratory tract infection between screening and the randomization visit must be screen
failed, and may be permitted to re-enroll at a later date. - Current smokers or ex-smokers
who stopped smoking within 6 months prior to screening or have a smoking history of ≥ 10
pack years. Other protocol-defined inclusion/exclusion criteria apply.