Endothelial Function, Arterial Stiffness and Components



Status:Completed
Conditions:Blood Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:8 - 28
Updated:3/30/2013
Start Date:June 2011
End Date:August 2012
Contact:Kathy Ruble, Phd
Email:rubleka@jhmi.edu
Phone:410-614-5062

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Trial Summary
Trial Overview
Inclusion Criteria

Endothelial Function, Arterial Stiffness and Components of Metabolic Syndrome in Acute Lymphoblastic Leukemia (ALL) Survivors


Specific Aim: Compare the endothelial function, arterial stiffness and components of
metabolic syndrome of childhood Acute Lymphoblastic Leukemia (ALL) survivors to healthy
sibling controls. Plan: A cross sectional study comparing ALL survivors to sibling controls
including measures of endothelial function and arterial stiffness obtained form a peripheral
artery tonometry device, height, weight, waist circumference, fasting lipid, glucose and
insulin.


Inclusion Criteria:

Survivor:

Inclusion

1. Ages 8-28 (8 is chosen as lower age limit because developmental understanding will
allow survivor to follow instructions for procedures, 28 is chosen as upper limit to
include age ranges seen for treatment in the pediatric program)

2. Off therapy for at least 6 months and not more than 10 years (6 months

Inclusion

1. Biological sibling

2. Ages 8-28 (when more than one sibling is available the one closest in age will be
chosen.))

Exclusion Criteria:

1. Uncontrolled medical conditions that could interfere with participation or
interpretation of results

2. History of relapsed ALL or history of bone marrow transplantation
We found this trial at
1
site
Johns Hopkins Hospital
1800 Orleans St.
Baltimore, Maryland 21287
410-955-5000
Johns Hopkins Hospital Patients are the focus of everything we do at The Johns Hopkins...
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