Open Label Study of Long Term Evaluation Against LDL-C Trial



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 75
Updated:11/4/2018
Start Date:October 7, 2011
End Date:June 20, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Multicenter, Controlled, Open-label Extension (OLE) Study to Assess the Long-term Safety and Efficacy of AMG 145 (Evolocumab)

The primary clinical hypothesis is that long-term exposure of evolocumab (AMG 145) will be
safe and well tolerated in subjects with hypercholesterolemia.


Inclusion Criteria:

- Complete a qualifying evolocumab (AMG 145) parent study protocol

Exclusion Criteria:

- Experienced a treatment-related serious adverse event that led to IP discontinuation
in the parent study

- Have an unstable medical condition, in the judgment of the investigator

- Known sensitivity to any of the products to be administered during dosing

- Currently enrolled in another investigational device or drug study (excluding
evolocumab (AMG 145) parent study), or less than 30 days since ending another
investigational device or drug study(s),or receiving other investigational agent(s)
We found this trial at
70
sites
Clinical Trial Facility in Camperdown New South Wales
Camperdown, New South Wales 2050
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Camperdown,
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Clinical Trial Facility in Akron Ohio
Akron, Ohio
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Akron, OH
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Clinical Trial Facility in Anaheim California
Anaheim, California 92801
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Anaheim, CA
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Clinical Trial Facility in Arlington Texas
Arlington, Texas 76017
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Arlington, TX
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
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Atlanta, GA
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Clinical Trial Facility in Auburn Maine
Auburn, Maine 04210
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Auburn, ME
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Clinical Trial Facility in Bethesda Maryland
Bethesda, Maryland
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Bethesda, MD
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
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Birmingham, AL
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Clinical Trial Facility in Bristol Tennessee
Bristol, Tennessee 37620
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Bristol, TN
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Clinical Trial Facility in Brockton Massachusetts
Brockton, Massachusetts 02301
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Brockton, MA
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Clinical Trial Facility in Brooklyn Center Minnesota
Brooklyn Center, Minnesota 55430
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Brooklyn Center, MN
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Clinical Trial Facility in Cadiz Ohio
Cadiz, Ohio 43907
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Cadiz, OH
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Clinical Trial Facility in Camp Hill Pennsylvania
Camp Hill, Pennsylvania 17011
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Camp Hill, PA
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Clinical Trial Facility in Carmichael California
Carmichael, California 95608
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Carmichael, CA
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Clinical Trial Facility in Chevy Chase Maryland
Chevy Chase, Maryland 20815
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Chevy Chase, MD
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Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
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Chicago, IL
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
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Cincinnati, OH
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Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
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Cleveland, OH
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Clinical Trial Facility in Colorado Springs Colorado
Colorado Springs, Colorado 80910
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Colorado Springs, CO
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Clinical Trial Facility in Cortlandt Manor New York
Cortlandt Manor, New York 10567
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Cortlandt Manor, NY
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Clinical Trial Facility in Dayton Ohio
Dayton, Ohio 45409
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Dayton, OH
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Clinical Trial Facility in Daytona Beach Florida
Daytona Beach, Florida 32117
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Daytona Beach, FL
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Clinical Trial Facility in DeLand Florida
DeLand, Florida 32720
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DeLand, FL
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Clinical Trial Facility in Duncansville Pennsylvania
Duncansville, Pennsylvania 16635
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Duncansville, PA
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Clinical Trial Facility in Endwell New York
Endwell, New York
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Endwell, NY
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Clinical Trial Facility in Fargo North Dakota
Fargo, North Dakota 58122
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Fargo, ND
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Clinical Trial Facility in Great Falls Montana
Great Falls, Montana 59405
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Great Falls, MT
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Clinical Trial Facility in Green Cove Springs Florida
Green Cove Springs, Florida
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Green Cove Springs, FL
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Clinical Trial Facility in Henderson Nevada
Henderson, Nevada
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Henderson, NV
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Clinical Trial Facility in Houston Texas
Houston, Texas
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Houston, TX
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Clinical Trial Facility in Indianapolis Indiana
Indianapolis, Indiana 46202
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Indianapolis, IN
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Clinical Trial Facility in Inglewood California
Inglewood, California 90301
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Inglewood, CA
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Clinical Trial Facility in Iowa City Iowa
Iowa City, Iowa 52242
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Iowa City, IA
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Clinical Trial Facility in Jacksonville Florida
Jacksonville, Florida 32209
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Jacksonville, FL
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Clinical Trial Facility in Las Vegas Nevada
Las Vegas, Nevada 89135
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Las Vegas, NV
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Clinical Trial Facility in Little Rock Arkansas
Little Rock, Arkansas
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Little Rock, AR
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Clinical Trial Facility in Littleton Colorado
Littleton, Colorado 80120
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Littleton, CO
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Clinical Trial Facility in Louisville Kentucky
Louisville, Kentucky 40202
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Louisville, KY
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Clinical Trial Facility in Malvern Arkansas
Malvern, Arkansas 72104
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Malvern, AR
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Clinical Trial Facility in Marquette Michigan
Marquette, Michigan
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Marquette, MI
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Clinical Trial Facility in Melbourne Florida
Melbourne, Florida
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Melbourne, FL
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Clinical Trial Facility in Miami Florida
Miami, Florida 33136
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Miami, FL
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Clinical Trial Facility in Mission Viejo California
Mission Viejo, California 92691
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Mission Viejo, CA
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Clinical Trial Facility in Mount Pleasant South Carolina
Mount Pleasant, South Carolina 29464
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Mount Pleasant, SC
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Clinical Trial Facility in Munster Indiana
Munster, Indiana 46321
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Munster, IN
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Clinical Trial Facility in New York New York
New York, New York 10032
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New York, NY
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Clinical Trial Facility in Newport Beach California
Newport Beach, California 92660
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Newport Beach, CA
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Clinical Trial Facility in Norfolk Virginia
Norfolk, Virginia 23507
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Norfolk, VA
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Clinical Trial Facility in Norman Oklahoma
Norman, Oklahoma 73069
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Norman, OK
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Clinical Trial Facility in Oklahoma City Oklahoma
Oklahoma City, Oklahoma
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Oklahoma City, OK
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Clinical Trial Facility in Pittsburgh Pennsylvania
Pittsburgh, Pennsylvania
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Pittsburgh, PA
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Clinical Trial Facility in Ponte Vedra Florida
Ponte Vedra, Florida 32081
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Ponte Vedra, FL
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Clinical Trial Facility in Port Charlotte Florida
Port Charlotte, Florida 33952
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Port Charlotte, FL
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Clinical Trial Facility in Portland Maine
Portland, Maine 04102
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Portland, ME
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Clinical Trial Facility in Raleigh North Carolina
Raleigh, North Carolina 27607
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Raleigh, NC
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Clinical Trial Facility in Rapid City South Dakota
Rapid City, South Dakota 57701
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Rapid City, SD
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Clinical Trial Facility in Renton Washington
Renton, Washington 98057
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Renton, WA
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Clinical Trial Facility in Richmond Virginia
Richmond, Virginia 23227
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Richmond, VA
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Clinical Trial Facility in San Antonio Texas
San Antonio, Texas 78224
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San Antonio, TX
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Clinical Trial Facility in Sanford Florida
Sanford, Florida 32771
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Sanford, FL
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Clinical Trial Facility in Savannah Georgia
Savannah, Georgia 31406
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Savannah, GA
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Clinical Trial Facility in Seattle Washington
Seattle, Washington 98105
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Seattle, WA
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Clinical Trial Facility in Tacoma Washington
Tacoma, Washington
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Tacoma, WA
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Clinical Trial Facility in Thousand Oaks California
Thousand Oaks, California 91360
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Thousand Oaks, CA
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Clinical Trial Facility in Tucson Arizona
Tucson, Arizona 85724
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Tucson, AZ
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Clinical Trial Facility in Tupelo Mississippi
Tupelo, Mississippi 38801
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Tupelo, MS
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Clinical Trial Facility in Tustin California
Tustin, California 92780
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Tustin, CA
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Clinical Trial Facility in Williamsville New York
Williamsville, New York 14221
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Williamsville, NY
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Clinical Trial Facility in Winston-Salem North Carolina
Winston-Salem, North Carolina
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Winston-Salem, NC
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Clinical Trial Facility in York Pennsylvania
York, Pennsylvania 17405
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York, PA
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