Open Label Study of Long Term Evaluation Against LDL-C Trial



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 75
Updated:11/4/2018
Start Date:October 7, 2011
End Date:June 20, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Multicenter, Controlled, Open-label Extension (OLE) Study to Assess the Long-term Safety and Efficacy of AMG 145 (Evolocumab)

The primary clinical hypothesis is that long-term exposure of evolocumab (AMG 145) will be
safe and well tolerated in subjects with hypercholesterolemia.


Inclusion Criteria:

- Complete a qualifying evolocumab (AMG 145) parent study protocol

Exclusion Criteria:

- Experienced a treatment-related serious adverse event that led to IP discontinuation
in the parent study

- Have an unstable medical condition, in the judgment of the investigator

- Known sensitivity to any of the products to be administered during dosing

- Currently enrolled in another investigational device or drug study (excluding
evolocumab (AMG 145) parent study), or less than 30 days since ending another
investigational device or drug study(s),or receiving other investigational agent(s)
We found this trial at
70
sites
Clinical Trial Facility in Tustin California
Tustin, California 92780
1152
mi
from
Tustin, CA
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Clinical Trial Facility in Akron Ohio
Akron, Ohio
898
mi
from
Akron, OH
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Clinical Trial Facility in Anaheim California
Anaheim, California 92801
1157
mi
from
Anaheim, CA
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Clinical Trial Facility in Arlington Texas
Arlington, Texas 76017
353
mi
from
Arlington, TX
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
801
mi
from
Atlanta, GA
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Clinical Trial Facility in Auburn Maine
Auburn, Maine 04210
1497
mi
from
Auburn, ME
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Clinical Trial Facility in Bethesda Maryland
Bethesda, Maryland
1123
mi
from
Bethesda, MD
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
683
mi
from
Birmingham, AL
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Clinical Trial Facility in Bristol Tennessee
Bristol, Tennessee 37620
864
mi
from
Bristol, TN
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Clinical Trial Facility in Brockton Massachusetts
Brockton, Massachusetts 02301
1445
mi
from
Brockton, MA
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Clinical Trial Facility in Brooklyn Center Minnesota
Brooklyn Center, Minnesota 55430
556
mi
from
Brooklyn Center, MN
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Clinical Trial Facility in Cadiz Ohio
Cadiz, Ohio 43907
918
mi
from
Cadiz, OH
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Clinical Trial Facility in Camp Hill Pennsylvania
Camp Hill, Pennsylvania 17011
1132
mi
from
Camp Hill, PA
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Clinical Trial Facility in Camperdown New South Wales
Camperdown, New South Wales 2050
8650
mi
from
Camperdown,
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Clinical Trial Facility in Carmichael California
Carmichael, California 95608
1274
mi
from
Carmichael, CA
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Clinical Trial Facility in Chevy Chase Maryland
Chevy Chase, Maryland 20815
1123
mi
from
Chevy Chase, MD
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Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
610
mi
from
Chicago, IL
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
726
mi
from
Cincinnati, OH
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Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
895
mi
from
Cleveland, OH
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Clinical Trial Facility in Colorado Springs Colorado
Colorado Springs, Colorado 80910
383
mi
from
Colorado Springs, CO
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Clinical Trial Facility in Cortlandt Manor New York
Cortlandt Manor, New York 10567
1294
mi
from
Cortlandt Manor, NY
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Clinical Trial Facility in Dayton Ohio
Dayton, Ohio 45409
746
mi
from
Dayton, OH
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Clinical Trial Facility in Daytona Beach Florida
Daytona Beach, Florida 32117
1128
mi
from
Daytona Beach, FL
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Clinical Trial Facility in DeLand Florida
DeLand, Florida 32720
?
mi
from
DeLand, FL
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Clinical Trial Facility in Duncansville Pennsylvania
Duncansville, Pennsylvania 16635
1052
mi
from
Duncansville, PA
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Clinical Trial Facility in Endwell New York
Endwell, New York
1189
mi
from
Endwell, NY
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Clinical Trial Facility in Fargo North Dakota
Fargo, North Dakota 58122
635
mi
from
Fargo, ND
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Clinical Trial Facility in Great Falls Montana
Great Falls, Montana 59405
958
mi
from
Great Falls, MT
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Clinical Trial Facility in Green Cove Springs Florida
Green Cove Springs, Florida
1067
mi
from
Green Cove Springs, FL
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Clinical Trial Facility in Henderson Nevada
Henderson, Nevada
954
mi
from
Henderson, NV
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Clinical Trial Facility in Houston Texas
Houston, Texas
569
mi
from
Houston, TX
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Clinical Trial Facility in Indianapolis Indiana
Indianapolis, Indiana 46202
643
mi
from
Indianapolis, IN
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Clinical Trial Facility in Inglewood California
Inglewood, California 90301
1176
mi
from
Inglewood, CA
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Clinical Trial Facility in Iowa City Iowa
Iowa City, Iowa 52242
429
mi
from
Iowa City, IA
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Clinical Trial Facility in Jacksonville Florida
Jacksonville, Florida 32209
1053
mi
from
Jacksonville, FL
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Clinical Trial Facility in Las Vegas Nevada
Las Vegas, Nevada 89135
971
mi
from
Las Vegas, NV
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Clinical Trial Facility in Little Rock Arkansas
Little Rock, Arkansas
372
mi
from
Little Rock, AR
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Clinical Trial Facility in Littleton Colorado
Littleton, Colorado 80120
407
mi
from
Littleton, CO
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Clinical Trial Facility in Louisville Kentucky
Louisville, Kentucky 40202
657
mi
from
Louisville, KY
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Clinical Trial Facility in Malvern Arkansas
Malvern, Arkansas 72104
364
mi
from
Malvern, AR
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Clinical Trial Facility in Marquette Michigan
Marquette, Michigan
807
mi
from
Marquette, MI
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Clinical Trial Facility in Melbourne Florida
Melbourne, Florida
1198
mi
from
Melbourne, FL
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Clinical Trial Facility in Miami Florida
Miami, Florida 33136
1320
mi
from
Miami, FL
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Clinical Trial Facility in Mission Viejo California
Mission Viejo, California 92691
1147
mi
from
Mission Viejo, CA
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Clinical Trial Facility in Mount Pleasant South Carolina
Mount Pleasant, South Carolina 29464
1065
mi
from
Mount Pleasant, SC
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Clinical Trial Facility in Munster Indiana
Munster, Indiana 46321
608
mi
from
Munster, IN
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Clinical Trial Facility in New York New York
New York, New York 10032
1290
mi
from
New York, NY
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Clinical Trial Facility in Newport Beach California
Newport Beach, California 92660
1158
mi
from
Newport Beach, CA
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Clinical Trial Facility in Norfolk Virginia
Norfolk, Virginia 23507
1181
mi
from
Norfolk, VA
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Clinical Trial Facility in Norman Oklahoma
Norman, Oklahoma 73069
176
mi
from
Norman, OK
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Clinical Trial Facility in Oklahoma City Oklahoma
Oklahoma City, Oklahoma
158
mi
from
Oklahoma City, OK
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Clinical Trial Facility in Pittsburgh Pennsylvania
Pittsburgh, Pennsylvania
971
mi
from
Pittsburgh, PA
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Clinical Trial Facility in Ponte Vedra Florida
Ponte Vedra, Florida 32081
1091
mi
from
Ponte Vedra, FL
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Clinical Trial Facility in Port Charlotte Florida
Port Charlotte, Florida 33952
1177
mi
from
Port Charlotte, FL
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Clinical Trial Facility in Portland Maine
Portland, Maine 04102
1492
mi
from
Portland, ME
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Clinical Trial Facility in Raleigh North Carolina
Raleigh, North Carolina 27607
1064
mi
from
Raleigh, NC
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Clinical Trial Facility in Rapid City South Dakota
Rapid City, South Dakota 57701
520
mi
from
Rapid City, SD
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Clinical Trial Facility in Renton Washington
Renton, Washington 98057
1382
mi
from
Renton, WA
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Clinical Trial Facility in Richmond Virginia
Richmond, Virginia 23227
1111
mi
from
Richmond, VA
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Clinical Trial Facility in San Antonio Texas
San Antonio, Texas 78224
583
mi
from
San Antonio, TX
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Clinical Trial Facility in Sanford Florida
Sanford, Florida 32771
1136
mi
from
Sanford, FL
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Clinical Trial Facility in Savannah Georgia
Savannah, Georgia 31406
1026
mi
from
Savannah, GA
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Clinical Trial Facility in Seattle Washington
Seattle, Washington 98105
1410
mi
from
Seattle, WA
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Clinical Trial Facility in Tacoma Washington
Tacoma, Washington
1407
mi
from
Tacoma, WA
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Clinical Trial Facility in Thousand Oaks California
Thousand Oaks, California 91360
1201
mi
from
Thousand Oaks, CA
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Clinical Trial Facility in Tucson Arizona
Tucson, Arizona 85724
833
mi
from
Tucson, AZ
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Clinical Trial Facility in Tupelo Mississippi
Tupelo, Mississippi 38801
561
mi
from
Tupelo, MS
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Clinical Trial Facility in Williamsville New York
Williamsville, New York 14221
1064
mi
from
Williamsville, NY
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Clinical Trial Facility in Winston-Salem North Carolina
Winston-Salem, North Carolina
976
mi
from
Winston-Salem, NC
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Clinical Trial Facility in York Pennsylvania
York, Pennsylvania 17405
1149
mi
from
York, PA
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