Open Label Study of Long Term Evaluation Against LDL-C Trial



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 75
Updated:11/4/2018
Start Date:October 7, 2011
End Date:June 20, 2018

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Multicenter, Controlled, Open-label Extension (OLE) Study to Assess the Long-term Safety and Efficacy of AMG 145 (Evolocumab)

The primary clinical hypothesis is that long-term exposure of evolocumab (AMG 145) will be
safe and well tolerated in subjects with hypercholesterolemia.


Inclusion Criteria:

- Complete a qualifying evolocumab (AMG 145) parent study protocol

Exclusion Criteria:

- Experienced a treatment-related serious adverse event that led to IP discontinuation
in the parent study

- Have an unstable medical condition, in the judgment of the investigator

- Known sensitivity to any of the products to be administered during dosing

- Currently enrolled in another investigational device or drug study (excluding
evolocumab (AMG 145) parent study), or less than 30 days since ending another
investigational device or drug study(s),or receiving other investigational agent(s)
We found this trial at
70
sites
Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
492
mi
from 43215
Birmingham, AL
Click here to add this to my saved trials
Clinical Trial Facility in Akron Ohio
Akron, Ohio
110
mi
from 43215
Akron, OH
Click here to add this to my saved trials
Clinical Trial Facility in Anaheim California
Anaheim, California 92801
1962
mi
from 43215
Anaheim, CA
Click here to add this to my saved trials
Clinical Trial Facility in Arlington Texas
Arlington, Texas 76017
933
mi
from 43215
Arlington, TX
Click here to add this to my saved trials
Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
436
mi
from 43215
Atlanta, GA
Click here to add this to my saved trials
Clinical Trial Facility in Auburn Maine
Auburn, Maine 04210
714
mi
from 43215
Auburn, ME
Click here to add this to my saved trials
Clinical Trial Facility in Bethesda Maryland
Bethesda, Maryland
323
mi
from 43215
Bethesda, MD
Click here to add this to my saved trials
Clinical Trial Facility in Bristol Tennessee
Bristol, Tennessee 37620
239
mi
from 43215
Bristol, TN
Click here to add this to my saved trials
Clinical Trial Facility in Brockton Massachusetts
Brockton, Massachusetts 02301
642
mi
from 43215
Brockton, MA
Click here to add this to my saved trials
Clinical Trial Facility in Brooklyn Center Minnesota
Brooklyn Center, Minnesota 55430
629
mi
from 43215
Brooklyn Center, MN
Click here to add this to my saved trials
Clinical Trial Facility in Cadiz Ohio
Cadiz, Ohio 43907
109
mi
from 43215
Cadiz, OH
Click here to add this to my saved trials
Clinical Trial Facility in Camp Hill Pennsylvania
Camp Hill, Pennsylvania 17011
322
mi
from 43215
Camp Hill, PA
Click here to add this to my saved trials
Clinical Trial Facility in Camperdown New South Wales
Camperdown, New South Wales 2050
9459
mi
from 43215
Camperdown,
Click here to add this to my saved trials
Clinical Trial Facility in Carmichael California
Carmichael, California 95608
2034
mi
from 43215
Carmichael, CA
Click here to add this to my saved trials
Clinical Trial Facility in Chevy Chase Maryland
Chevy Chase, Maryland 20815
323
mi
from 43215
Chevy Chase, MD
Click here to add this to my saved trials
Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
274
mi
from 43215
Chicago, IL
Click here to add this to my saved trials
Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
98
mi
from 43215
Cincinnati, OH
Click here to add this to my saved trials
Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
127
mi
from 43215
Cleveland, OH
Click here to add this to my saved trials
Clinical Trial Facility in Colorado Springs Colorado
Colorado Springs, Colorado 80910
1161
mi
from 43215
Colorado Springs, CO
Click here to add this to my saved trials
Clinical Trial Facility in Cortlandt Manor New York
Cortlandt Manor, New York 10567
487
mi
from 43215
Cortlandt Manor, NY
Click here to add this to my saved trials
Clinical Trial Facility in Dayton Ohio
Dayton, Ohio 45409
64
mi
from 43215
Dayton, OH
Click here to add this to my saved trials
Clinical Trial Facility in Daytona Beach Florida
Daytona Beach, Florida 32117
749
mi
from 43215
Daytona Beach, FL
Click here to add this to my saved trials
Clinical Trial Facility in DeLand Florida
DeLand, Florida 32720
?
mi
from 43215
DeLand, FL
Click here to add this to my saved trials
Clinical Trial Facility in Duncansville Pennsylvania
Duncansville, Pennsylvania 16635
243
mi
from 43215
Duncansville, PA
Click here to add this to my saved trials
Clinical Trial Facility in Endwell New York
Endwell, New York
393
mi
from 43215
Endwell, NY
Click here to add this to my saved trials
Clinical Trial Facility in Fargo North Dakota
Fargo, North Dakota 58122
857
mi
from 43215
Fargo, ND
Click here to add this to my saved trials
Clinical Trial Facility in Great Falls Montana
Great Falls, Montana 59405
1494
mi
from 43215
Great Falls, MT
Click here to add this to my saved trials
Clinical Trial Facility in Green Cove Springs Florida
Green Cove Springs, Florida
693
mi
from 43215
Green Cove Springs, FL
Click here to add this to my saved trials
Clinical Trial Facility in Henderson Nevada
Henderson, Nevada
1751
mi
from 43215
Henderson, NV
Click here to add this to my saved trials
Clinical Trial Facility in Houston Texas
Houston, Texas
991
mi
from 43215
Houston, TX
Click here to add this to my saved trials
Clinical Trial Facility in Indianapolis Indiana
Indianapolis, Indiana 46202
166
mi
from 43215
Indianapolis, IN
Click here to add this to my saved trials
Clinical Trial Facility in Inglewood California
Inglewood, California 90301
1980
mi
from 43215
Inglewood, CA
Click here to add this to my saved trials
Clinical Trial Facility in Iowa City Iowa
Iowa City, Iowa 52242
460
mi
from 43215
Iowa City, IA
Click here to add this to my saved trials
Clinical Trial Facility in Jacksonville Florida
Jacksonville, Florida 32209
668
mi
from 43215
Jacksonville, FL
Click here to add this to my saved trials
Clinical Trial Facility in Las Vegas Nevada
Las Vegas, Nevada 89135
1767
mi
from 43215
Las Vegas, NV
Click here to add this to my saved trials
Clinical Trial Facility in Little Rock Arkansas
Little Rock, Arkansas
622
mi
from 43215
Little Rock, AR
Click here to add this to my saved trials
Clinical Trial Facility in Littleton Colorado
Littleton, Colorado 80120
1164
mi
from 43215
Littleton, CO
Click here to add this to my saved trials
Clinical Trial Facility in Louisville Kentucky
Louisville, Kentucky 40202
188
mi
from 43215
Louisville, KY
Click here to add this to my saved trials
Clinical Trial Facility in Malvern Arkansas
Malvern, Arkansas 72104
662
mi
from 43215
Malvern, AR
Click here to add this to my saved trials
Clinical Trial Facility in Marquette Michigan
Marquette, Michigan
504
mi
from 43215
Marquette, MI
Click here to add this to my saved trials
Clinical Trial Facility in Melbourne Florida
Melbourne, Florida
832
mi
from 43215
Melbourne, FL
Click here to add this to my saved trials
Clinical Trial Facility in Miami Florida
Miami, Florida 33136
993
mi
from 43215
Miami, FL
Click here to add this to my saved trials
Clinical Trial Facility in Mission Viejo California
Mission Viejo, California 92691
1953
mi
from 43215
Mission Viejo, CA
Click here to add this to my saved trials
Clinical Trial Facility in Mount Pleasant South Carolina
Mount Pleasant, South Carolina 29464
524
mi
from 43215
Mount Pleasant, SC
Click here to add this to my saved trials
Clinical Trial Facility in Munster Indiana
Munster, Indiana 46321
259
mi
from 43215
Munster, IN
Click here to add this to my saved trials
Clinical Trial Facility in New York New York
New York, New York 10032
481
mi
from 43215
New York, NY
Click here to add this to my saved trials
Clinical Trial Facility in Newport Beach California
Newport Beach, California 92660
1963
mi
from 43215
Newport Beach, CA
Click here to add this to my saved trials
Clinical Trial Facility in Norfolk Virginia
Norfolk, Virginia 23507
422
mi
from 43215
Norfolk, VA
Click here to add this to my saved trials
Clinical Trial Facility in Norman Oklahoma
Norman, Oklahoma 73069
853
mi
from 43215
Norman, OK
Click here to add this to my saved trials
Clinical Trial Facility in Oklahoma City Oklahoma
Oklahoma City, Oklahoma
849
mi
from 43215
Oklahoma City, OK
Click here to add this to my saved trials
Clinical Trial Facility in Pittsburgh Pennsylvania
Pittsburgh, Pennsylvania
162
mi
from 43215
Pittsburgh, PA
Click here to add this to my saved trials
Clinical Trial Facility in Ponte Vedra Florida
Ponte Vedra, Florida 32081
727
mi
from 43215
Ponte Vedra, FL
Click here to add this to my saved trials
Clinical Trial Facility in Port Charlotte Florida
Port Charlotte, Florida 33952
897
mi
from 43215
Port Charlotte, FL
Click here to add this to my saved trials
Clinical Trial Facility in Portland Maine
Portland, Maine 04102
704
mi
from 43215
Portland, ME
Click here to add this to my saved trials
Clinical Trial Facility in Raleigh North Carolina
Raleigh, North Carolina 27607
371
mi
from 43215
Raleigh, NC
Click here to add this to my saved trials
Clinical Trial Facility in Rapid City South Dakota
Rapid City, South Dakota 57701
1071
mi
from 43215
Rapid City, SD
Click here to add this to my saved trials
Clinical Trial Facility in Renton Washington
Renton, Washington 98057
1982
mi
from 43215
Renton, WA
Click here to add this to my saved trials
Clinical Trial Facility in Richmond Virginia
Richmond, Virginia 23227
341
mi
from 43215
Richmond, VA
Click here to add this to my saved trials
Clinical Trial Facility in San Antonio Texas
San Antonio, Texas 78224
1144
mi
from 43215
San Antonio, TX
Click here to add this to my saved trials
Clinical Trial Facility in Sanford Florida
Sanford, Florida 32771
780
mi
from 43215
Sanford, FL
Click here to add this to my saved trials
Clinical Trial Facility in Savannah Georgia
Savannah, Georgia 31406
561
mi
from 43215
Savannah, GA
Click here to add this to my saved trials
Clinical Trial Facility in Seattle Washington
Seattle, Washington 98105
2005
mi
from 43215
Seattle, WA
Click here to add this to my saved trials
Clinical Trial Facility in Tacoma Washington
Tacoma, Washington
2012
mi
from 43215
Tacoma, WA
Click here to add this to my saved trials
Clinical Trial Facility in Thousand Oaks California
Thousand Oaks, California 91360
2003
mi
from 43215
Thousand Oaks, CA
Click here to add this to my saved trials
Clinical Trial Facility in Tucson Arizona
Tucson, Arizona 85724
1639
mi
from 43215
Tucson, AZ
Click here to add this to my saved trials
Clinical Trial Facility in Tupelo Mississippi
Tupelo, Mississippi 38801
506
mi
from 43215
Tupelo, MS
Click here to add this to my saved trials
Clinical Trial Facility in Tustin California
Tustin, California 92780
1958
mi
from 43215
Tustin, CA
Click here to add this to my saved trials
Clinical Trial Facility in Williamsville New York
Williamsville, New York 14221
304
mi
from 43215
Williamsville, NY
Click here to add this to my saved trials
Clinical Trial Facility in Winston-Salem North Carolina
Winston-Salem, North Carolina
306
mi
from 43215
Winston-Salem, NC
Click here to add this to my saved trials
Clinical Trial Facility in York Pennsylvania
York, Pennsylvania 17405
340
mi
from 43215
York, PA
Click here to add this to my saved trials