Developing Cognitive Training for Tourette Syndrome
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 9 - 17 |
| Updated: | 2/7/2015 |
| Start Date: | August 2011 |
| End Date: | December 2014 |
| Contact: | Han Joo Lee, Ph.D. |
| Email: | leehj@uwm.edu |
| Phone: | 414-229-5858 |
Developing Effective Response Inhibition Training for Symptom Relief in Tourette Syndrome
Many researchers suspect that individuals with Tourette Syndrome (TS) may have a poor
cognitive ability (i.e., response inhibition; RI) that is essential to inhibit inappropriate
response such as vocal or motor tics. The investigators aim to test whether a
well-established behavior therapy for TS can be improved by increasing the individual's RI
capabilities. To this end, 20 children will be randomly assigned to behavior therapy with
computer-based RI training or behavior therapy with placebo computer-based cognitive
training. The investigators will test the hypothesis that computer-based RI training can be
a useful addition to the well-established behavior therapy to enhance its therapeutic
effect.
cognitive ability (i.e., response inhibition; RI) that is essential to inhibit inappropriate
response such as vocal or motor tics. The investigators aim to test whether a
well-established behavior therapy for TS can be improved by increasing the individual's RI
capabilities. To this end, 20 children will be randomly assigned to behavior therapy with
computer-based RI training or behavior therapy with placebo computer-based cognitive
training. The investigators will test the hypothesis that computer-based RI training can be
a useful addition to the well-established behavior therapy to enhance its therapeutic
effect.
The current research seeks to examine the feasibility of using a computer-based RI training
program as an adjunctive intervention for the Comprehensive Behavioral Intervention for Tics
(CBIT). Our central hypothesis is that cognitive training designed to enhance RI will
potentiate treatment outcomes of CBIT. To this end, the investigators will conduct a two-arm
placebo-controlled double-blind trial, in which 20 children with TS will be randomly
assigned to CBIT with computerized RI training (CBIT+RIT; n=10) or CBIT with placebo
computer training (CBIT +PLT; n=10). CBIT consists of eight weekly sessions that present
awareness training, competing response training, relaxation training and functional
contingency management in a manualized format. The adjunctive computer training (RIT or PLT)
will be delivered during the first 4 weeks of CBIT/HRT (i.e. 8 twice-weekly 40-min
sessions). Tic symptoms and RI capabilities will be assessed at baseline, mid-treatment,
post-treatment, and 1 month follow-up. This project is expected to increase our
understanding about the nature of response inhibition deficits in TS and generate knowledge
that will guide the development of effective cognitive interventions for TS.
program as an adjunctive intervention for the Comprehensive Behavioral Intervention for Tics
(CBIT). Our central hypothesis is that cognitive training designed to enhance RI will
potentiate treatment outcomes of CBIT. To this end, the investigators will conduct a two-arm
placebo-controlled double-blind trial, in which 20 children with TS will be randomly
assigned to CBIT with computerized RI training (CBIT+RIT; n=10) or CBIT with placebo
computer training (CBIT +PLT; n=10). CBIT consists of eight weekly sessions that present
awareness training, competing response training, relaxation training and functional
contingency management in a manualized format. The adjunctive computer training (RIT or PLT)
will be delivered during the first 4 weeks of CBIT/HRT (i.e. 8 twice-weekly 40-min
sessions). Tic symptoms and RI capabilities will be assessed at baseline, mid-treatment,
post-treatment, and 1 month follow-up. This project is expected to increase our
understanding about the nature of response inhibition deficits in TS and generate knowledge
that will guide the development of effective cognitive interventions for TS.
Inclusion Criteria:
- age between 9 and 17
- a diagnosis of TS or chronic tic disorder on the structured diagnostic interview
- moderate to severe levels of tic symptoms (YGTSS total score > 13 for TS, or > 9 for
CTD), and (d) IQ > 80.
Exclusion Criteria:
- current substance abuse or dependence
- current or past psychotic disorder, bipolar disorder, or schizophrenia
- 4 or more previous sessions of behavioral treatments for tic
- significant suicidal ideation and/or attempts within the past 3 months
- any recent (in the previous month) or planned change in medication for tic symptoms.
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