Blood Sugars in Children With Idiopathic Seizures.
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Neurology, Endocrine |
| Therapuetic Areas: | Endocrinology, Neurology, Other |
| Healthy: | No |
| Age Range: | Any - 17 |
| Updated: | 4/2/2016 |
| Start Date: | February 2006 |
| End Date: | August 2007 |
| Contact: | Chetanbabu M Patel, MD |
| Email: | chpatel@cmh.edu |
| Phone: | 816-234-1660 |
Prevalence of Hypoglycemia and/or Hyperinsulinism/Hyperammonemia Syndrome in Patients With Idiopathic Seizures.
The purpose of this study is to determine if there is a significant percentage of children
with the diagnosis of idiopathic seizures who have undiagnosed or unrecognized hypoglycemia
(low blood sugar).
with the diagnosis of idiopathic seizures who have undiagnosed or unrecognized hypoglycemia
(low blood sugar).
Convulsive disorders are among the most frequently occurring neurologic conditions in
children. Idiopathic seizures are the most common (67.6%) type of seizure seen in the 0-15
year age group. The highest incidence is in the first year of life. In the United States, 5
percent of individuals experience a seizure of some type by the age of 20.
Seizures have multiple etiologies. These include hypoglycemia, congenital causes,
toxic/metabolic causes, infection, neoplasm, perinatal causes, and trauma. The medical
evaluation often includes blood work, imaging of the brain, and performing an
electroencephalogram. Currently, there is no consensus as to the work-up of children
presenting with unprovoked seizures.
Hypoglycemia presents with a wide spectrum of symptoms and severity. In children,
hypoglycemia can lead to seizures and coma. In neonates and infants, however, the symptoms
are even more varied and nonspecific. They can include cyanotic spells, apnea, respiratory
distress, refusal to feed, and myoclonic jerks. The varied symptoms of hypoglycemia make the
disorder difficult to diagnose.
The study will have parents checking blood sugars for 14 days and a one time ammonia level.
Blood sugar checks will be first thing in the morning and one hour after a meal. If the
study identifies a subset of patients with idiopathic seizures who have hypoglycemia, this
finding may have implications for future glucose screening recommendations.
children. Idiopathic seizures are the most common (67.6%) type of seizure seen in the 0-15
year age group. The highest incidence is in the first year of life. In the United States, 5
percent of individuals experience a seizure of some type by the age of 20.
Seizures have multiple etiologies. These include hypoglycemia, congenital causes,
toxic/metabolic causes, infection, neoplasm, perinatal causes, and trauma. The medical
evaluation often includes blood work, imaging of the brain, and performing an
electroencephalogram. Currently, there is no consensus as to the work-up of children
presenting with unprovoked seizures.
Hypoglycemia presents with a wide spectrum of symptoms and severity. In children,
hypoglycemia can lead to seizures and coma. In neonates and infants, however, the symptoms
are even more varied and nonspecific. They can include cyanotic spells, apnea, respiratory
distress, refusal to feed, and myoclonic jerks. The varied symptoms of hypoglycemia make the
disorder difficult to diagnose.
The study will have parents checking blood sugars for 14 days and a one time ammonia level.
Blood sugar checks will be first thing in the morning and one hour after a meal. If the
study identifies a subset of patients with idiopathic seizures who have hypoglycemia, this
finding may have implications for future glucose screening recommendations.
Inclusion Criteria:
- The inclusion criteria will be patients with idiopathic seizure disorders.
- The age range will be from birth to 17 years of age.
- Study subjects may be on anti-convulsants; the study does not alter current drug
therapy.
Exclusion Criteria:
- The exclusion criteria includes patients with known causes of seizure disorders,
including those with an underlying risk factor predisposing them to seizures. The
risk factors are:
1. congenital causes (CNS malformation, cerebral palsy)
2. CNS infection toxic/known metabolic abnormality
3. CNS neoplasm perinatal insults (birth trauma, asphyxia/hypoxia),
4. traumatic
5. All others who have an anatomic or known biochemical lesion.
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