A Study of S-297995 for the Treatment of Opioid-Induced Constipation in Subjects With Non-Malignant Chronic Pain Receiving Opioid Therapy

Inclusion Criteria:

- Subjects aged 18 years or older at time of informed consent with non-malignant
chronic pain experiencing opioid-induced constipation

- Subjects with <3 spontaneous bowel movements a week and experiencing bowel symptoms

- Subjects receiving chronic opioid therapy due to non-malignant pain for ≥3 months

Exclusion Criteria:

- Evidence of clinically significant gastrointestinal disease

- History of chronic constipation prior to starting analgesic medication or any
potential non-opioid cause of bowel dysfunction that may be a major contributor to
the constipation

- Severe constipation that has not been appropriately managed such that the subject is
at immediate risk of developing serious complications of constipation