COroNary CT Angiography Evaluation For Clinical Outcomes: An InteRnational Multicenter Registry (CONFIRM)

Coronary computed tomographic angiography (CCTA) of 64-detector rows or greater represents a
novel noninvasive anatomic method for evaluation of patients with suspected coronary artery
disease (CAD). Early studies suggest a potential for prognostic risk assessment by CCTA
findings but were limited by small patient cohorts or single centers. The CONFIRM Registry is
a large, prospective, multinational dynamic observational study of patients undergoing CCTA.
The primary aim of CONFIRM is to determine the prognostic value of CCTA findings for the
prediction of future adverse CAD events.

The CONFIRM registry currently represents 27,125 consecutive patients at 12 cluster sites in
6 countries in North America, Europe, and Asia. CONFIRM sites were chosen on the basis of
adequate CCTA volume, site CCTA proficiency, and local demographic characteristics and
medical facilities to ensure a broad-based sample of patients. Patients comprising the
present CONFIRM cohort include those with suspected but without known CAD, with known CAD, or
asymptomatic persons undergoing CAD evaluation. A data dictionary comprising a wide array of
demographic, clinical, and CCTA findings was developed by the CONFIRM investigators and is
uniformly used for all patients. Patients are followed up after CCTA performance to identify
adverse CAD events, including death, myocardial infarction, unstable angina, target vessel
revascularization, and CAD-related hospitalization.

All consecutive patients at cluster sites meeting all inclusion criteria undergoing CCTA of
64-detector rows or greater will be included within the CONFIRM registry.

Inclusion Criteria:

1. Age > 18 years

2. Evaluation by CCTA with 64-detector rows or greater for CAD evaluation as part of
standard of care

3. Interpretable CCTA

4. Prospective data collection for CAD risk factors.

Exclusion Criteria:

No explicit patient exclusion criteria are defined.