More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery

Inclusion Criteria:

- Subjects must have a clinically documented primary brain tumor for which resection is
clinically indicated. Individuals with suspected newly diagnosed or recurrent
malignant gliomas will be considered eligible for the study. The anticipated
histology at resection should include: Anaplastic astrocytoma (10002224), Anaplastic
ependymoma, Anaplastic oligodendroglioma, Astrocytoma malignant NOS (10003572),
Glioblastoma (10018336), Glioblastoma multiforme (10018337), or Gliosarcoma
(10018340).

- Prior therapy is not a consideration in protocol entry.

- Age 18-80.

- Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (Karnofsky ≥ 60%).

- Life expectancy is not a consideration for protocol entry.

- Subjects must have normal organ and marrow function as defined below:

- Leukocytes ≥ 3,000/mL

- Platelets ≥ 100,000/mL

- Total bilirubin below upper limit of normal

- Aspartate aminotransferase (AST) (SGOT)/alanine aminotransferase (ALT) (SGPT) ≤
2.5 X institutional upper limit of normal

- Creatinine below upper limit of normal OR

- Creatinine clearance ≥ 60 mL/min/1.73 m² for patients with creatinine levels
above institutional normal

- The effects of aminolevulinic acid (ALA) on the developing human fetus are unknown.
For this reason, women of child-bearing potential and men must agree to use adequate
contraception (hormonal or barrier method of birth control; abstinence) prior to
study entry and for the duration of study participation. Should a woman become
pregnant or suspect she is pregnant while participating in this study, she should
inform her treating physician immediately. A pregnancy test will be performed for all
women of childbearing ability prior to surgery. Women who are pregnant will be
excluded from the trial.

- Ability to understand and the willingness to sign a written informed consent
document.

Exclusion Criteria:

- Tumors of or involving the midline, basal ganglia, or brain stem as assessed by MRI.

- Subjects may not be receiving any experimental therapies.

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to aminolevulinic acid (ALA). Patients should refrain from use of other
potential phototoxic substances (e.g. tetracyclines, sulfonamides,fluoroquinolones,
hypericin extracts) for 72 hours.

- Personal or family history of porphyrias.

- Uncontrolled intercurrent illness including, but not limited to ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements. Pregnant women are excluded from this study because
aminolevulinic acid (ALA) is of unknown teratogenic or abortifacient effects. Because
there is an unknown but potential risk for adverse events in nursing infants
secondary to treatment of the mother with aminolevulinic acid (ALA), breastfeeding
should be discontinued if the mother is treated with aminolevulinic acid (ALA).

- Women who are pregnant will be excluded from the trial.

- Prior history of GI perforation, diverticulitis, and/or peptic ulcer disease.

- Inclusion of women and minorities: both men and women and members of all ethnic
groups are eligible for this trial.