REASON 1 Trial: Sonography in Cardiac Arrest

This is a multi-center, prospective, observational trial involving sites across the United
States and Canada. Patients will be enrolled through the emergency department either
presenting in cardiac arrest, or going into cardiac arrest while in the emergency
department. Patients who develop cardiac arrest as inpatients will also be enrolled at
centers capable of enrolling inpatients subjects. Advanced Cardiac Life Support (ACLS)
protocols and institutional policies for resuscitation will be followed, as is the current
standard of care. A patient encounter will conclude upon halting of cardiopulmonary
resuscitation. Final disposition of the patient will be evaluated by chart review.

After the initial cardiac arrest and disposition there will be no further direct patient
interactions as part of the study except in the setting of repeat cardiac arrest. Patients
that have a repeat arrest can undergo a repeated ultrasound exam if they continue to meet
inclusion criteria. The repeat episode will be recorded as a continuation of the event and
not as a separate enrollment.

Subject data, with Protected Health Information (PHI) removed, will be uploaded into the
REDcap web-based database as soon as possible and within 7 days of final disposition. Data
will be obtained from initial patient encounter, patient records, and EMS records when
available. Additional data may be obtained by chart review to obtain data points not
available at initial contact. Individual sites will keep secured records to enable
identification of the patient source if data review is required.

Patient information will include 6 types of data, past medical history, events surrounding
the cardiac arrest, actions taken by health care professionals, peri-arrest presentation,
peri-arrest interventions, and patient outcomes. Health care professional actions can
include ACLS medication administration, airway management, chest compressions,
defibrillation, pacing, and other resuscitative interventions. Specific data points are
listed in the paper version of electronic Case Report Form, CRF, see Appendix A.

Sonography will not hinder or impair resuscitative efforts in any way, including halting CPR
or prolonging pauses in cardiopulmonary rescusitation (CPR). Sonographic images will be
obtained during designated pauses in chest compressions, as is routine care, during CPR for
pulse checks, rhythm checks, and necessary resuscitative procedures.

Single or multi-view echocardiography will be performed as appropriate to obtain diagnostic
information for each particular patient during resuscitative efforts. Recording of the image
loops will be performed during image acquisition according to standard technology
availability at each site. To facilitate image acquisition, the ultrasound probe may be
placed in the epigastrium or parasternal region during CPR with the heart centered in the
field of view, if it will not interfere with ongoing resuscitation. Recording of the images
can begin immediately upon pauses of CPR using whatever means are available at the site.
Sonographic images will be obtained by competent personnel with experience in bedside
cardiac ultrasound. This information will be made available to the physician taking care of
the patient

Ultrasound images will consist of a single or multiple view(s) that can include subxiphoid,
parasternal long axis, and/or apical 4 chamber. While not primarily preferred views; also
acceptable are parasternal short axis or apical 2 chamber views. Image requirements will be
based on adequate echocardiographic windows and adequate image acquisition as determined by
the physician performing the bedside ultrasound. In the setting of difficult to image
patients a combination of views may be required to obtain adequate information.

There will be at least two ultrasound exams performed. The initial ultrasound exam and video
will be obtained upon the first pause for pulse or rhythm check once the inclusion criteria
are met and no exclusion criteria are present. The final ultrasound exam and video will be
obtained when resuscitative efforts are halted.

All ultrasound images will be recorded for later review by the Regional Coordinating Site
for each Local Site. Ultrasound videos will be interpreted during acquisition as cardiac
activity present or absent and valvular movement present or absent. Specific video file
formats that are acceptable include MPEG4, Quicktime (MOV), DV, AVI, and WMV. Files will be
forwarded at least monthly to the Site Coordinator for the Regional Site and sent within 1
week of request by the regional coordinating site.

INITIAL INTERPRETATION OF CARDIAC IMAGES The Local Site PI will interpret ultrasound images
and the information will be uploaded into the central database or another database specified
by the Central Coordinating Site. Cardiac activity will initially categorize as "Cardiac
Activity Present", "Cardiac Activity Absent", Valve Movement Present", or Valve Movement
Absent". Cardiac activity is defined as any intrinsic movement of the myocardium, but not
isolated movement of the cardiac valves. Valve movement is defined as any movement of the
cardiac valves.

FINAL INTERPRETATION OF CARDIAC IMAGES

Cardiac images will be reviewed by regional site PIs for sub-categories of cardiac activity.
A heart with any intrinsic cardiac movement outside of isolated valvular motion will be
categorized as "Cardiac Activity Present". Ultrasound images in patients with cardiac
activity will be further categorized as:

1. Cardiac motion but No decrease in chamber size

2. Cardiac motion with a decrease in chamber size <10%

3. Cardiac motion with a decrease in chamber size of >10%.

The estimated duration that each subject will participate is the length of the
cardiopulmonary resuscitation which can vary by patient, but can be from 15 minutes to 1
hour, with later follow up (hours to days later) to determine final disposition.

A summary of the sequence and duration of all research activities is as follows.

Patient interactions (estimated 15 minutes to 1 hour)

- Patient identified to be in cardiac arrest with confirmation of no pulse.

- Chest compressions and ACLS protocols initiated as per standard care

- Bedside ultrasound of heart performed and interpreted during standard pauses in cardiac
compressions as per routine care at institution (3-6 seconds)

- ACLS protocols continue as per standard care by treating physician

- Resuscitation activities halted by either pronouncement of patient or return of
spontaneous circulation allowing disposition planning

- Bedside ultrasound of heart performed and interpreted (3-6 seconds)

Data Acquisition (Immediate to days later via chart review)

- Final patient disposition determined

- Interval events recorded (ie: repeat cardiopulmonary arrest)

Data Management (immediate to days or weeks later)

- Subject data with PHI removed entered into research database

- Subject data with PHI removed updated in research database if CRF not completed
initially

- Cardiac ultrasound images with PHI removed sent to regional site for review

Inclusion Criteria:

- Patients in cardiac arrest with no pulse

Exclusion Criteria:

- Patients with isolated ventricular fibrillation as their cardiac rhythm at the time
of presentation

- Traumatic cardiopulmonary arrest

- Ultrasound system or physician experienced in bedside cardiac ultrasound not
available

- Resuscitative efforts halted due to end of life decisions or designations

- Attending physician of record declines enrollment of patient