A Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior
| Status: | Completed |
|---|---|
| Conditions: | Depression, Psychiatric, Endocrine |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any - 19 |
| Updated: | 11/8/2014 |
| Start Date: | September 2011 |
| End Date: | June 2014 |
| Contact: | Laura Mufson, PhD |
| Email: | MufsonL@nyspi.columbia.edu |
| Phone: | 212-543-5561 |
An Open Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior
The investigators are adapting Interpersonal Psychotherapy (IPT-A) for adolescents who are
referred to emergency services either for a suicide attempt or for being evaluated as high
risk for suicidal behavior. The investigators will recruit 15 adolescents ages 12-19 years
who present with a diagnosis of major depression, dysthymic disorder, depression disorder
not otherwise specified who have a history of a suicide attempt in the past 2 months or a
non-medically lethal attempt that may require psychiatric hospitalization, suicide attempt
that is or report current suicidal ideation with a plan/intent, and treat them in an open
clinical trial. The treatment will be conducted twice weekly for the first 8 weeks of
treatment and then weekly for the remaining 12 weeks of the study. Using feedback from
clinicians and participants, the investigators will make further modifications to the manual
in preparation for conducting a larger controlled clinical trial.
referred to emergency services either for a suicide attempt or for being evaluated as high
risk for suicidal behavior. The investigators will recruit 15 adolescents ages 12-19 years
who present with a diagnosis of major depression, dysthymic disorder, depression disorder
not otherwise specified who have a history of a suicide attempt in the past 2 months or a
non-medically lethal attempt that may require psychiatric hospitalization, suicide attempt
that is or report current suicidal ideation with a plan/intent, and treat them in an open
clinical trial. The treatment will be conducted twice weekly for the first 8 weeks of
treatment and then weekly for the remaining 12 weeks of the study. Using feedback from
clinicians and participants, the investigators will make further modifications to the manual
in preparation for conducting a larger controlled clinical trial.
All treatment will be done on the Children's Day Unit (CDU) and the adolescent and his/her
family need to agree to participate in the CDU program. The acute phase is biweekly for 8
weeks followed by weekly sessions for the remaining 12 weeks to allow for continued work on
the skills and for consolidation of skills to prevent relapse. It is a total of 28 sessions
in 20 weeks. There also are up to 4 additional emergency sessions that can be used to handle
crises or have additional parent sessions during those 20 weeks. In addition, the child and
adolescent psychiatrist will evaluate each study participant in terms of presently
prescribed medication or for the need to initiate pharmacological treatment which will
follow the evidence based medicine recommendations for pediatric psychopharmacology (Walkup
et al., 2009). The child and adolescent psychiatrist will see each study participant weekly
for monitoring of illness severity and medication management. Over the course of the 20 week
treatment, the investigators will assess their diagnosis, global functioning, severity of
depression, anxiety and suicidal ideation, and family factors. At each therapy session, the
adolescents will be assessed for suicidal behavior by their clinician. They also will be
seen every 4 weeks by an independent evaluator who will track their symptoms and functioning
at weeks 4, 8, 12, 16, 20 or early termination and week 32 follow-up assessments. The open
trial will allow us to determine the feasibility of recruiting depressed and suicidal youth.
It also will allow us to determine the benefits of using IPT-A to treat depressed and
suicidal youth.
family need to agree to participate in the CDU program. The acute phase is biweekly for 8
weeks followed by weekly sessions for the remaining 12 weeks to allow for continued work on
the skills and for consolidation of skills to prevent relapse. It is a total of 28 sessions
in 20 weeks. There also are up to 4 additional emergency sessions that can be used to handle
crises or have additional parent sessions during those 20 weeks. In addition, the child and
adolescent psychiatrist will evaluate each study participant in terms of presently
prescribed medication or for the need to initiate pharmacological treatment which will
follow the evidence based medicine recommendations for pediatric psychopharmacology (Walkup
et al., 2009). The child and adolescent psychiatrist will see each study participant weekly
for monitoring of illness severity and medication management. Over the course of the 20 week
treatment, the investigators will assess their diagnosis, global functioning, severity of
depression, anxiety and suicidal ideation, and family factors. At each therapy session, the
adolescents will be assessed for suicidal behavior by their clinician. They also will be
seen every 4 weeks by an independent evaluator who will track their symptoms and functioning
at weeks 4, 8, 12, 16, 20 or early termination and week 32 follow-up assessments. The open
trial will allow us to determine the feasibility of recruiting depressed and suicidal youth.
It also will allow us to determine the benefits of using IPT-A to treat depressed and
suicidal youth.
Inclusion Criteria:
- Males and females ages 12-19 years
- English speaking adolescent
- Parent may be monolingual or bilingual in Spanish
- DSM-IV diagnosis of MDD, dysthymia, DDNOS
- Moderate impairment in functioning
- Moderate to severe depression severity
- Expressed risk for suicide or reported non-medically lethal attempt. Non-lethal
attempt is defined as an attempt that did not require medical hospitalization but may
require psychiatric hospitalization which often includes being in the Emergency Room
for several days because there was no bed available.
Exclusion Criteria:
- Suicide attempt in the past 4 months with medical lethality that requires
hospitalization which often includes being in the ER for several days because there
was no bed available.
- Severe impairment in functioning
- Diagnoses of Substance abuse, Schizophrenia, bipolar disorder,Conduct disorder,
primary eating disorder, Psychosis, obsessive-compulsive disorder,
- Engagement in self-injurious that requires medical treatment in the past month
- Mental retardation or severe learning disability
- Medical illness that may interfere with treatment
- Current physical or sexual abuse
- Open Administration for Children's Services (ACS) case
- Pregnancy
- Already receiving treatment for depression or have begun a medication trial for
another diagnosis within the previous three months
We found this trial at
2
sites
New York State Psychiatric Institute The New York State Psychiatric Institute (NYSPI), established in 1895,...
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