Exercise Dose Response for Improving Insulin Sensitivity
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 4/21/2016 |
| Start Date: | January 2009 |
| End Date: | December 2015 |
Comparing the Effects Exercise Intensity and Energy Expended During a Single Exercise Session on Insulin Sensitivity and Fatty Acid Partitioning Within Skeletal Muscle the Next Day in Obese Adults.
Many of the beneficial metabolic effects of endurance exercise training are not due to
adaptations to weeks, months, or even years of training, but rather much is due to the
response to the most recent exercise session(s). Therefore, the investigators contend that
lifestyle interventions for obese individuals should be tailored to optimize the metabolic
effects of the most recent exercise session(s). But the "dose" of exercise necessary to
evoke these beneficial responses is not known, and the mechanisms responsible for these
improvements are poorly understood. The findings from these studies will: 1) establish the
minimum "dose" of a single exercise session necessary to improve insulin sensitivity the
next day in obese adults, 2) characterize the underlying metabolic factors responsible for
the improvement in insulin sensitivity, and 3) assess the cumulative metabolic adaptations
that occur over days, weeks, and months of a low-intensity/low-volume lifestyle exercise
program. Findings from these studies will provide valuable information for the development
of lifestyle programs aimed at maximizing the key metabolic health benefits of each exercise
session in obese patients.
adaptations to weeks, months, or even years of training, but rather much is due to the
response to the most recent exercise session(s). Therefore, the investigators contend that
lifestyle interventions for obese individuals should be tailored to optimize the metabolic
effects of the most recent exercise session(s). But the "dose" of exercise necessary to
evoke these beneficial responses is not known, and the mechanisms responsible for these
improvements are poorly understood. The findings from these studies will: 1) establish the
minimum "dose" of a single exercise session necessary to improve insulin sensitivity the
next day in obese adults, 2) characterize the underlying metabolic factors responsible for
the improvement in insulin sensitivity, and 3) assess the cumulative metabolic adaptations
that occur over days, weeks, and months of a low-intensity/low-volume lifestyle exercise
program. Findings from these studies will provide valuable information for the development
of lifestyle programs aimed at maximizing the key metabolic health benefits of each exercise
session in obese patients.
Inclusion Criteria:
- Body Mass Index [BMI] = 30-45 kg/m2, weight stable (± 5 lbs in the past month),
fasting blood glucose concentration must be <125 mg/dl.
Exclusion Criteria:
- pregnancy, evidence of cardiovascular or metabolic disease, taking medications know
to influence metabolism.
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