Relationship Between Systemic Fatty Acid Availability and Insulin Sensitivity
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 7/5/2018 |
| Start Date: | September 2011 |
| End Date: | July 2025 |
| Contact: | Suzette Howton, RD |
| Email: | suzetter@med.umich.edu |
| Phone: | 734-647-9850 |
The investigators specific aim is to compare the relationship between systemic fatty acid
availability and insulin sensitivity in a relatively homogenous population of obese adults.
The investigators anticipate 1) greater systemic fatty acid availability will be associated
with lower insulin sensitivity and 2) greater systemic fatty acid availability will be
associated with greater accumulation of fatty acid intermediates and pro-inflammatory
markers.
availability and insulin sensitivity in a relatively homogenous population of obese adults.
The investigators anticipate 1) greater systemic fatty acid availability will be associated
with lower insulin sensitivity and 2) greater systemic fatty acid availability will be
associated with greater accumulation of fatty acid intermediates and pro-inflammatory
markers.
Inclusion Criteria:
- Body mass index [BMI]: 35-45 kg/m2; All women must be pre-menopausal; Non-exerciser
(no regularly planned exercise/physical activity)
Exclusion Criteria:
- Weight instability ≥ ±5 lbs. in past month; medications known to affect lipid and/or
glucose metabolism; Pregnancy or actively breast feeding
We found this trial at
1
site
Ann Arbor, Michigan 48109
Principal Investigator: Jeffrey F Horowitz, Ph.D.
Phone: 734-647-9850
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