Evaluating the Validity of a Genetic Risk Assessment Tool in Identifying Autism Spectrum Disorder
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Psychiatric, Autism |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 1 - 12 |
| Updated: | 3/1/2014 |
| Start Date: | January 2012 |
| Contact: | Allison Voorman |
| Email: | voormaa@ccf.org |
| Phone: | 216.448.6421 |
Understanding Genetic Differences Associated With Autism Spectrum and Attention Deficit/Hyperactivity Disorder
There are three purposes to this study. The first purpose is to evaluate the value of a
genetic test in determining risk for autism spectrum disorder. Processing for genetic
samples will be completed at the Cleveland Clinic using research equipment provided by
IntegraGen. The second purpose is to identify genetic changes that may be associated with
autism spectrum disorder or attention deficit/hyperactivity disorder. The third purpose is
to examine whether genetic differences and changes may predict which individuals benefit
from medicine used to treat attention problems or other psychiatric difficulties.
Between 600-800 people are expected to participate in this study - approximately 300
individuals with an autism spectrum disorder, 75 individuals with attention
deficit/hyperactivity disorder or another developmental or psychiatric disorder, 100 healthy
siblings, and 125 unrelated individuals without a developmental or psychiatric disorder.
Study procedures will vary based upon the specific group participants are suspected to fall
into (autism, attention deficit/hyperactivity disorder, psychiatric concerns/developmental
delay, healthy sibling, or unrelated healthy control).
- All individuals will be asked to participate in a cheek swab (gently swabbing the
inside of your cheek) to obtain cells used for genetic testing. Genetic material will
be stored with identifiers such as numbers, letters or codes.
- Parents or caregivers will be asked to complete questionnaires that examine medical and
family history as well as current symptoms and quality of life for the participant.
- Participants may undergo speech and language testing. This involves answering
questions, looking at pictures or identifying items.
- Information recorded in participant medical records will be reviewed and collected for
this study.
genetic test in determining risk for autism spectrum disorder. Processing for genetic
samples will be completed at the Cleveland Clinic using research equipment provided by
IntegraGen. The second purpose is to identify genetic changes that may be associated with
autism spectrum disorder or attention deficit/hyperactivity disorder. The third purpose is
to examine whether genetic differences and changes may predict which individuals benefit
from medicine used to treat attention problems or other psychiatric difficulties.
Between 600-800 people are expected to participate in this study - approximately 300
individuals with an autism spectrum disorder, 75 individuals with attention
deficit/hyperactivity disorder or another developmental or psychiatric disorder, 100 healthy
siblings, and 125 unrelated individuals without a developmental or psychiatric disorder.
Study procedures will vary based upon the specific group participants are suspected to fall
into (autism, attention deficit/hyperactivity disorder, psychiatric concerns/developmental
delay, healthy sibling, or unrelated healthy control).
- All individuals will be asked to participate in a cheek swab (gently swabbing the
inside of your cheek) to obtain cells used for genetic testing. Genetic material will
be stored with identifiers such as numbers, letters or codes.
- Parents or caregivers will be asked to complete questionnaires that examine medical and
family history as well as current symptoms and quality of life for the participant.
- Participants may undergo speech and language testing. This involves answering
questions, looking at pictures or identifying items.
- Information recorded in participant medical records will be reviewed and collected for
this study.
Inclusion Criteria:
- Diagnosis of Autistic Disorder, Pervasive Developmental Disorder, or Asperger's
Disorder or have a clinical diagnosis of another developmental or psychiatric
disorder (developmental/psychiatric controls), or have no specific developmental or
psychiatric diagnosis (healthy controls).
- Age 1 to 12.
Exclusion Criteria:
- For individuals with ASD and developmental concern controls, presence of a known or
strongly suspected genetic disorder based on all available clinical data.
- Age less than 1 or greater than 12.
- Individuals for whom DNA is not available for analysis.
- Individuals for whom it is anticipated that they will not be available for follow-up
at the Cleveland Clinic during the study period.
- Any medical diagnoses that might preclude participation in a low risk,
non-interventional research study and any participant who at the discretion of the
clinical investigator is not medically able to participate in the study (e.g., unable
to comply with cheek swab or other procedure or has serious medical condition which
precludes participation).
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