Alkali Therapy in Chronic Kidney Disease
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 4/25/2018 |
| Start Date: | October 2011 |
| End Date: | August 2016 |
Placebo-controlled Randomized Clinical Trial of Alkali Therapy in Patients With Chronic Kidney Disease
Kidney disease is a common medical condition. Individuals with kidney disease develop a
build-up of acid in their blood. This acid can affect their muscles, bones, glucose
metabolism and kidneys. The investigators will test alkali treatment, to treat acid build-up,
in a randomized placebo-controlled clinical trial to evaluate effects on muscles, bones,
glucose metabolism and kidney.
build-up of acid in their blood. This acid can affect their muscles, bones, glucose
metabolism and kidneys. The investigators will test alkali treatment, to treat acid build-up,
in a randomized placebo-controlled clinical trial to evaluate effects on muscles, bones,
glucose metabolism and kidney.
Inclusion Criteria:
- Estimate GFR <= 45 and >15 ml/min/1.73m2
- Age >18
Exclusion Criteria:
- Previous chronic treatment with alkali within the last 3 months (including sodium
bicarbonate, calcium carbonate or baking soda)
- bicarbonate level <20 or >25 mEq/L
- New York Heart Association Class III or IV heart failure
- Systolic blood pressure >180 mmHg
- Initiation of ESRD treatment planned within 6 months
- Kidney transplantation
- Treatment with immunosuppressives within the last 3 months
We found this trial at
2
sites
Albert Einstein College of Medicine The Albert Einstein College of Medicine of Yeshiva University is...
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Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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