Pharmacokinetics Study of Oral IXAZOMIB in Participants With Advanced Nonhematologic Malignancies or Lymphoma

Inclusion Criteria:

- Male or female participants 18 years or older.

- Participants must have a diagnosis of histologically or cytologically confirmed
metastatic and/or advanced solid tumor malignancy or lymphoma for which no effective
standard treatment is available.

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.

- Female participants who are postmenopausal at least 1 year, or surgically sterile, or
if of childbearing potential, agree to practice 2 effective methods of contraception,
at the same time from the time of signing the consent form through 90 days after the
last dose of study drug, or agree to practice true abstinence.

- Male participants, even if surgically sterilized, agree to practice effective barrier
contraception during the entire study treatment period and through 90 days after the
last dose of study drug or agree to practice true abstinence.

- Voluntary written informed consent.

- Clinical laboratory values as specified in protocol.

- Suitable venous access.

- Recovered (that is, less than [< ] Grade 1 toxicity or participant's baseline status)
from the reversible effects of prior anticancer therapy.

Exclusion Criteria:

- Peripheral neuropathy greater than (>) Grade 2 on clinical examination.

- Systemic treatment with strong inhibitors of cytochrome P450 (CYP) 1A2, strong
inhibitors of CYP3A, or strong CYP3A inducers or use of ginkgo biloba or St. John's
wort within 14 days before the first dose of IXAZOMIB.

- Participant has symptomatic brain metastasis. Participants with brain metastases must:
have stable neurologic status following surgery or radiation for at least 2 weeks
after completion of the definitive therapy; and be without neurologic dysfunction that
would confound the evaluation of neurologic and other adverse events.

- Female participants who are pregnant or lactating.

- Serious illness that could interfere with protocol completion.

- Autologous stem cell transplant within 6 months before Day 1 of Cycle 1, or prior
allogeneic stem cell transplant at any time.

- Prior treatment with rituximab or other unconjugated any antibody treatment within 42
days (21 days if there is clear evidence of progressive disease or immediate treatment
is mandated).

- Ongoing treatment with corticosteroids.

- Radiotherapy within 21 days before the first dose of study drug.

- Major surgery within 14 days before the first dose of study drug.

- Infection requiring systemic antibiotic therapy or other serious infection within 14
days prior to first dose of study drug.

- Life-threatening illness unrelated to cancer.

- Known human immunodeficiency virus (HIV) positive, hepatitis B surface
antigen-positive, or suspected hepatitis C infection.

- Diagnosis or treatment of another malignancy within 2 years preceding first dose, or
previously diagnosed with another malignancy and have any evidence of residual
disease. Participants with nonmelanoma skin cancer or carcinoma in situ of any type
are not excluded if they have undergone complete resection.

- Evidence of uncontrolled cardiovascular conditions.

- QTc > 500 milliseconds on a 12-lead electrocardiogram (ECG).

- Known gastrointestinal disease or procedure that could interfere with the oral
absorption or tolerance of IXAZOMIB including difficulty swallowing capsules; diarrhea
> Grade 1 despite supportive therapy.

- Participants with gastric achlorhydria (Arm 1 only).

- Participants who have used any nicotine containing products within 14 days before the
first dose of study drug (Arm 1, Arm 4, and Arm 5).

- Treatment with any investigational products or systemic antineoplastic therapies
within 21 days before the first dose of IXAZOMIB.

- Participants with known hypersensitivity to macrolide antibiotics (example,
clarithromycin, erythromycin, azithromycin) or a history of jaundice/liver injury
during prior exposure to clarithromycin (Arm 5 only).