Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapy



Status:Recruiting
Conditions:Other Indications, Blood Cancer, Hematology
Therapuetic Areas:Hematology, Oncology, Other
Healthy:No
Age Range:18 - Any
Updated:5/3/2014
Start Date:January 2012
End Date:September 2016
Contact:Novartis Pharmaceuticals
Phone:1-888-669-6682

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A Single-arm Dose-finding Phase Ib Multicenter Study of the Oral Smoothened Antagonist LDE225 in Combination With Nilotinib in Chronic or Accelerated Phase of Chronic Myeloid Leukemia Patients Who Have Failed Prior Therapy With Other BCR-ABL Tyrosine-kinase Inhibitors

The purpose of this study is to determine the feasibility of administering the combination
of nilotinib and LDE225 to patients with chronic or accelerated phase of chronic myeloid
leukemia and to establish the maximum tolerated dose (MTD) and/or recommended Phase II dose
level (RP2D) of LDE225 in combination with nilotinib.


Inclusion Criteria:

1. Philadelphia chromosome positive (Ph+) CML in chronic phase (CP) or accelerated phase
(AP)with resistance to at least one prior BCR-ABL targeting TKI

2. Documented chronic phase CML

3. Adequate end organ function

4. Female patients of childbearing potential must have a negative serum pregnancy test
and must be using highly effective methods of contraception. Male patients with
female partners of child-bearing potential must use condoms.

Exclusion Criteria:

1. Impaired cardiac function

2. Severe and/or uncontrolled concurrent disease that in the opinion of the investigator
could cause unacceptable safety risks or compromise compliance with the protocol

3. History of acute pancreatitis within 1 year of study entry or past medical history of
chronic pancreatitis

4. Patients actively receiving therapy with strong CYP3A4 inhibitors and/or inducers,
and the treatment cannot be either discontinued or switched to a different medication
prior to entering the study

5. Patients who are currently receiving treatment with any medications that have the
potential to prolong the QT interval and the treatment cannot be either safely
discontinued or switched to a different medication prior to starting study drug.

6. Previously documented BCR-ABL Y253H, E255K/V, T315I or F359C/V mutation

Other protocol-defined inclusion/exclusion criteria may apply.
We found this trial at
7
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Duarte, CA
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Chicago, Illinois 60611
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Durham, North Carolina 27710
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Houston, Texas 77024
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