A Study To Evaluate Both The Efficacy and Safety Profile of CP-690,550 In Patients With Moderately to Severely Active Ulcerative Colitis



Status:Completed
Conditions:Colitis, Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:June 2012
End Date:June 2015

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Multicentre, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Of Oral Cp-690,550 As An Induction Therapy In Subjects With Moderate To Severe Ulcerative Colitis.

This study is designed to evaluate the efficacy and safety of tofacitinib (CP-690,550) in
patients with moderate to severe ulcerative colitis who have failed or be intolerant to one
of following treatments for ulcerative colitis: oral steroids,
azathiopurine/6-mercaptopurine, or anti-TNF-alpha therapy.


Inclusion Criteria:

- Subject must be at least 18 years of age.

- Males and females with a documented diagnosis of UC at least 4 months prior to entry
into the study.

- Subjects with moderately to severely active UC based on Mayo score criteria.

- Subjects must have failed or be intolerant of at least one of the following
treatments for UC:

- Corticosteroids (oral or intravenous).

- Azathioprine or 6 mercaptopurine (6 MP).

- Anti TNF therapy.

Exclusion Criteria:

- Presence of indeterminate colitis, microscopic colitis, ischemic colitis, infectious
colitis, or clinical findings suggestive of Crohn's disease.

- Subjects with disease limited to distal 15 cm.

- Subjects without previous treatment for UC (ie, treatment naïve).

- Subjects displaying clinical signs of fulminant colitis or toxic megacolon.
We found this trial at
62
sites
Dartmouth Hitchcock Medical Center
1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
?
mi
from
Lebanon, NH
Click here to add this to my saved trials
University of Texas Health Science Center at Houston
7000 Fannin St
Houston, Texas 77030
(713) 500-4472
University of Texas Health Science Center at Houston The University of Texas Health Science Center...
?
mi
from
Houston, TX
Click here to add this to my saved trials
Advanced Medical Research Center
1690 Dunlawton Ave # 220
Port Orange, Florida 32127
?
mi
from
Port Orange, FL
Click here to add this to my saved trials
University of Rochester
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
University of Rochester The University of Rochester is one of the country's top-tier research universities....
?
mi
from
Rochester, NY
Click here to add this to my saved trials
Texas Clinical Research Institiute
Arlington, Texas 76012
?
mi
from
Arlington, TX
Click here to add this to my saved trials
Austin Gastroenterology, PA
Austin, Texas 78705
?
mi
from
Austin, TX
Click here to add this to my saved trials
Austin Gastroenterology PA/Professional Quality Research, Inc.
Austin, Texas 78705
?
mi
from
Austin, TX
Click here to add this to my saved trials
Bristol Hospital
Bristol, Connecticut 06010
?
mi
from
Bristol, CT
Click here to add this to my saved trials
Connecticut Clinical Research Foundation
Bristol, Connecticut 06010
?
mi
from
Bristol, CT
Click here to add this to my saved trials
Clinical Research Institute of Michigan,
Chesterfield, Michigan 48098
?
mi
from
Chesterfield, MI
Click here to add this to my saved trials
Metropolitan Gastroenterology Group, PC Chevy Chase Clinical Research
Chevy Chase, Maryland 20815
?
mi
from
Chevy Chase, MD
Click here to add this to my saved trials
Chevy Chase Endoscopy Center (Endoscopies only)
Chevy Chase, Maryland 20815
?
mi
from
Chevy Chase, MD
Click here to add this to my saved trials
Surgery Center of Columbia
Columbia, Missouri 65201
?
mi
from
Columbia, MO
Click here to add this to my saved trials
Citrus Surgery & Endoscopy Center (Colonoscopy)
Crystal River, Florida 34429
?
mi
from
Crystal River, FL
Click here to add this to my saved trials
Atlanta Center for Gastroenterology, P.C.
Decatur, Georgia 30033
?
mi
from
Decatur, GA
Click here to add this to my saved trials
AGA Clinical Research Associates, LLC
Egg Harbor Township, New Jersey 08234
?
mi
from
Egg Harbor Township, NJ
Click here to add this to my saved trials
Carolina Research - Carolina Digestive Diseases
Greenville, North Carolina 27834
?
mi
from
Greenville, NC
Click here to add this to my saved trials
Hannibal Regional Hospital
Hannibal, Missouri 63401
?
mi
from
Hannibal, MO
Click here to add this to my saved trials
Memorial Hermann Hospital
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Nature Coast Clinical Research
Inverness, Florida 34452
?
mi
from
Inverness, FL
Click here to add this to my saved trials
Suncoast Endoscopy Center (colonoscopy)
Inverness, Florida 34453
?
mi
from
Inverness, FL
Click here to add this to my saved trials
Regional Gastroenterology Associates of Lancaster, LTD
Lancaster, Pennsylvania 17604
?
mi
from
Lancaster, PA
Click here to add this to my saved trials
South Jersey Gastroenterology
Marlton, New Jersey 08053
?
mi
from
Marlton, NJ
Click here to add this to my saved trials
Audrain Medical Center
Mexico, Missouri 65265
?
mi
from
Mexico, MO
Click here to add this to my saved trials
Center for Digestive & Liver Disease, Inc.
Mexico, Missouri 65265
?
mi
from
Mexico, MO
Click here to add this to my saved trials
Gastroenterology Group of Naples
Naples, Florida 34102
?
mi
from
Naples, FL
Click here to add this to my saved trials
Vanderbilt University Medical Center - Drug Shipment
Nashville, Tennessee 37232
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Vanderbilt University Medical Center - GCRC
Nashville, Tennessee 37232
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Vanderbilt University Medical Center - GI Research Office
Nashville, Tennessee 37212
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Vanderbilt University Medical Center - Heart Station
Nashville, Tennessee 37232
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Vanderbilt University Medical Center - IBD Clinic
Nashville, Tennessee 37212
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Vanderbilt University Medical Center - Radiology
Nashville, Tennessee 37232
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Yale-New Haven Hospital
20 York St, N20 York St,
New Haven, Connecticut 06520
(203) 688-4242
Yale-New Haven Hospital Relying on the skill and expertise of more than 4,500 university and...
?
mi
from
New Haven, CT
Click here to add this to my saved trials
Yale University School of Medicine
333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
?
mi
from
New Haven, CT
Click here to add this to my saved trials
Alliance Clinical Research
Oceanside, California 92056
?
mi
from
Oceanside, CA
Click here to add this to my saved trials
Central Connecticut Endoscopy Center
Plainville, Connecticut 06062
?
mi
from
Plainville, CT
Click here to add this to my saved trials
Advanced Gastroenterology Center
Port Orange, Florida 32127
?
mi
from
Port Orange, FL
Click here to add this to my saved trials
Endoscopy Center
Port Orange, Florida 32127
?
mi
from
Port Orange, FL
Click here to add this to my saved trials
Port Orange Urgent Care
Port Orange, Florida 32127
?
mi
from
Port Orange, FL
Click here to add this to my saved trials
VCU Health System Digestive Health Center
Richmond, Virginia 23298
?
mi
from
Richmond, VA
Click here to add this to my saved trials
VCU Health System Endoscopy Suite
Richmond, Virginia 23298
?
mi
from
Richmond, VA
Click here to add this to my saved trials
VCU Medical Center Investigational Drug Service (IDS)
Richmond, Virginia 23298
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Virginia Commonwealth University
Richmond, Virginia 23298
(804) 828-0100
Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
?
mi
from
Richmond, VA
Click here to add this to my saved trials
The Mayo Clinic
Rochester, Minnesota 55905
?
mi
from
Rochester, MN
Click here to add this to my saved trials
Clinical Application Laboratories, Inc.
San Diego, California 92103
?
mi
from
San Diego, CA
Click here to add this to my saved trials
San Diego Endoscopy Center
San Diego, California 92103
?
mi
from
San Diego, CA
Click here to add this to my saved trials
Medical Center at Mount Zion
San Francisco, California 94115
?
mi
from
San Francisco, CA
Click here to add this to my saved trials
UCSF Endoscopy Unit at Mount Zion
San Francisco, California 94115
?
mi
from
San Francisco, CA
Click here to add this to my saved trials
University of California at San Francisco
San Francisco, California 94143
?
mi
from
San Francisco, CA
Click here to add this to my saved trials
Gastrointestinal Specialists, A.M.C.
Shreveport, Louisiana 71103
?
mi
from
Shreveport, LA
Click here to add this to my saved trials
Louisiana Research Center, LLC
Shreveport, Louisiana 71103
?
mi
from
Shreveport, LA
Click here to add this to my saved trials
Shreveport Endoscopy Center, A.M.C.
Shreveport, Louisiana 71103
?
mi
from
Shreveport, LA
Click here to add this to my saved trials
Cotton-O'Neil Clinical Research Center, Digestive Health
Topeka, Kansas 66606
?
mi
from
Topeka, KS
Click here to add this to my saved trials
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center
Torrance, California 90502
?
mi
from
Torrance, CA
Click here to add this to my saved trials
Center for Digestive Health
Troy, Michigan 48098
?
mi
from
Troy, MI
Click here to add this to my saved trials
Surgical Centers of Michigan
Troy, Michigan 48098
?
mi
from
Troy, MI
Click here to add this to my saved trials
Desert Sun Clinical Research, LCC
Tucson, Arizona 85710
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
Desert Sun Gastroenterology
Tucson, Arizona 85710
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
Desert Sun Surgery Center
Tucson, Arizona 85710
?
mi
from
Tucson, AZ
Click here to add this to my saved trials
Digestive Health Specialists of Tyler
Tyler, Texas 75701
?
mi
from
Tyler, TX
Click here to add this to my saved trials
The Gastroenterology Group of South Jersey
Vineland, New Jersey 08360
?
mi
from
Vineland, NJ
Click here to add this to my saved trials
The Endo Center at Voorhees
Voorhees, New Jersey 08043
?
mi
from
Voorhees, NJ
Click here to add this to my saved trials