Proton Pump Inhibitors and Dysbiosis in Cirrhosis
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 4/17/2018 |
| Start Date: | October 2011 |
| End Date: | February 2018 |
The purpose of this study is to find out whether the use of medications that suppress acid in
your stomach can change the composition of your bowel bacteria.
your stomach can change the composition of your bowel bacteria.
Inclusion Criteria for PPI initiation study:
- Cirrhosis not on current PPI or acid suppressive therapy
- No systemic antibiotics or probiotics
Exclusion Criteria for PPI initiation study:
- On systemic antibiotics
- On PPI or acid suppression therapy already
- unable to give informed consent
- Allergy to proton pump inhibitors
Inclusion Criteria for PPI withdrawal study:
- Cirrhosis on current PPI for an FDA-unapproved indication
- No systemic antibiotics or probiotics
Exclusion Criteria for PPI withdrawal study:
- On systemic absorbable antibiotics
- On PPI or acid suppression therapy for an FDA-approved indication
- unable to give informed consent
- unwilling to withdraw PPI
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