Problems With Immune Recovery in the Gut Tissue
| Status: | Completed |
|---|---|
| Conditions: | HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/30/-0001 |
| Start Date: | September 2008 |
| End Date: | August 2013 |
| Contact: | Ann Seguin, RN |
| Email: | segu0017@umn.edu |
| Phone: | 612-625-7472 |
A Compartmental Analysis of HIV Reservoirs and Immune Reconstitution (C)
The aim of this study is to find out if the process of HIV replication in the lymph tissue
and gut tissue of people taking HIV drugs causes long-term damage to the ability of the gut
to protect you from other infections and health problems.
Inclusion Criteria:
HIV+ individuals
- Seropositive for HIV
- On ART for at least 12 months
- Seropositive to HSV2 and CMV
- Age ≥ 18 years
- Negative pregnancy test for eligible women of childbearing potential
HIV- individuals
- Seronegative for HIV
- Seropositive for HSV2 and CMV
- Age ≥ 18 years
- Negative pregnancy test for eligible women of childbearing potential
Exclusion Criteria:
- Taking daily suppressive therapy for HSV2
- Contraindication to surgical & endoscopic procedures (as judged by PI)
- Psychiatric or psychological illness that would make adherence to protocol procedures
unlikely
- Pregnancy
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