Brentuximab Vedotin in Patients With CD30-positive Nonlymphomatous Malignancies



Status:Completed
Conditions:Cancer, Blood Cancer, Anemia, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:6 - Any
Updated:4/21/2016
Start Date:October 2011
End Date:December 2014

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A Phase 2, Open-label Study of Brentuximab Vedotin in Patients With CD30-positive Nonlymphomatous Malignancies

This is an open-label, multicenter, phase 2 clinical trial to evaluate the antitumor
activity of brentuximab vedotin as a single agent in patients with CD30-positive
nonlymphomatous malignancies.


Inclusion Criteria:

- Histologically-confirmed by central review CD30-positive nonlymphomatous malignancy

- Have failed, refused, or have been deemed ineligible for standard therapy

- Measurable disease

- Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1 or a
Karnofsky or Lansky Performance Status score greater than or equal to 70

Exclusion Criteria:

- Primary diagnosis of lymphoma or central nervous system (CNS) malignancy

- History of another primary invasive malignancy that has not been definitively treated
or in remission for at least 3 years

- Evidence of active cerebral/meningeal disease
We found this trial at
29
sites
Albany, New York 12206
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Albany, NY
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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433 Southwest 10th Street
Ocala, Florida 34471
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Ocala, FL
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Aurora, CO
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Bedford, Texas 76022
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Bedford, TX
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Blacksburg, VA
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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Cleveland, OH
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Dallas, TX
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Dallas, TX
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Denton, Texas 76210
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Denton, TX
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Duarte, California 91010
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Duarte, CA
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Edmonds, Washington 98026
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Edmonds, WA
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Eugene, OR
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Fairfax, VA
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Fort Worth, TX
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Greenville, South Carolina 29601
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Greenville, SC
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Houston, TX
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Houston, TX
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Indianapolis, Indiana 46202
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Indianapolis, IN
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Jacksonville, Florida 32224
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Jacksonville, FL
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Minneapolis, Minnesota 55405
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Minneapolis, MN
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Oxnard, CA
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Round Rock, TX
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San Antonio, Texas 78229
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San Antonio, TX
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Spokane Valley, Washington 99216
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Spokane Valley, WA
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Tulatin, Oregon 97062
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Tulatin, OR
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Waco, Texas 76712
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Waco, TX
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2811 Tieton Drive
Yakima, Washington 98902
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Yakima, WA
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