Exercise Trial in Chronic Kidney Disease
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 60 - 85 |
| Updated: | 12/14/2018 |
| Start Date: | March 2012 |
| End Date: | October 31, 2017 |
Randomized Trial of Aerobic Exercise Training on Cognitive and Physical Function in Chronic Kidney Disease
Chronic Kidney Disease (CKD) is exceedingly common in older adults, in whom it is associated
with impairment in cognition and physical function. The purpose of this study is to test the
effects of 12 months of aerobic and resistance exercise training compared to health education
on cognitive and physical performance in 120 older adults with CKD not requiring dialysis.
The results of this study will be essential for demonstrating the effectiveness of exercise
in improving function and ultimately preventing disability in this high-risk population of
older adults.
with impairment in cognition and physical function. The purpose of this study is to test the
effects of 12 months of aerobic and resistance exercise training compared to health education
on cognitive and physical performance in 120 older adults with CKD not requiring dialysis.
The results of this study will be essential for demonstrating the effectiveness of exercise
in improving function and ultimately preventing disability in this high-risk population of
older adults.
This is a parallel-group randomized controlled trial comparing 12 months of aerobic and
resistance exercise training vs. health education (attention control) on neurocognitive and
physical performance among community-dwelling older adults (age >55) and CKD stage 3b and 4.
Co-primary outcomes are change in physical performance (including aerobic capacity and
submaximal walking) and neurocogntivie performance (including executive functions).
Outcome measures will be assessed at baseline and after 6- and 12 months. Exercise training
will occur thrice weekly at a dedicated research exercise center and will be supervised by
exercise specialists.
resistance exercise training vs. health education (attention control) on neurocognitive and
physical performance among community-dwelling older adults (age >55) and CKD stage 3b and 4.
Co-primary outcomes are change in physical performance (including aerobic capacity and
submaximal walking) and neurocogntivie performance (including executive functions).
Outcome measures will be assessed at baseline and after 6- and 12 months. Exercise training
will occur thrice weekly at a dedicated research exercise center and will be supervised by
exercise specialists.
Inclusion Criteria:
- Stage 3-4 Chronic kidney disease (estimated GFR 15-45)
- Age 60 to 85
- English Speaking
Exclusion Criteria:
- Dementia or cognitive impairment
- Renal transplant
- NY Heart Association class 3-4 heart failure
- Severe Chronic Lung Disease
- Unstable angina or coronary revascularization within the last 3 months
- Orthopedic problems that would preclude aerobic exercise training
- Known, untreated infection
- Disabling arthritis
- Uncontrolled arrhythmia
- More than 14 alcoholic drinks per week
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