Virtual Integrated Environment in Decreasing Phantom Limb Pain

Nearly all traumatic limb amputees will experience cognizance of a phantom limb and perceive
a vivid impression that their lost limb is not only fully present, but also painful. The
John Hopkins University Applied Physics Laboratory Virtual Integration Environment (VIE) is
a highly flexible and adaptable virtual reality system that allows patients to observe
movement of a 3D virtual arm. Using the VIE, recorded signals from the residual limb will be
correlated to the desired motion of the phantom limb. We hope to correlate the consistency
of these patterns with PLP to determine if increased control of the phantom limb leads to
decreased PLP.

Inclusion Criteria:

- Male or female subjects, 18 to 65 years of age, active duty military, beneficiary, or
retiree.

- Written informed consent and written authorization for use or release of health and
research study information.

- At least one upper-limb amputation (trans radial or trans humeral) at any time prior
to enrollment.

- No prior history of vertebral disk disease/condition, sciatica or radiculopathy.

- Normal neurological examination with the exception of limb amputation.

- Ability to follow study instructions and likely to complete all required visits.

- Experiencing PLP at least 3 times a week at an intensity of at least 3 out of 10 at
the time of enrollment.

Exclusion Criteria:

- Presence of mild to severe traumatic brain injury - permanent or temporary
impairments of cognitive, physical, and psychosocial functions with an associated
diminished or altered state of consciousness - as indicated by neuropsychological
screening that is currently performed routinely on patients by the traumatic brain
injury (TBI) program at Walter Reed National Military Medical Center (WRNMMC) and
noted in the patient's medical record.

- Known uncontrolled systemic disease

- Participation (either concurrently or in the 30 days prior to enrollment) in another
study for treatment of PLP

- Any condition or situation that, in the investigator's opinion, may put the subject
at significant risk, confound study results, or interfere significantly with the
subject's participation in the study.

- Significant Axis I or II diagnosis determined by a neurologist or psychiatrist in the
6 months prior to entry into the study

- Subjects with lack of effort as determined by the neurologist or psychiatrist.
Subjects will be screened for effort using the Test of Memory Malingering (TOMM) in
order to exclude those with blatant exaggeration or malingering. Subjects who score
lower than 42/50 on the TOMM-2 will not continue in the study