A Study of LY3007113 in Participants With Advanced Cancer
Status: | Completed |
---|---|
Conditions: | Cancer, Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 8/9/2018 |
Start Date: | December 2011 |
End Date: | December 2013 |
A Phase 1 Study of LY3007113, a p38 MAPK Inhibitor, in Patients With Advanced Cancer
This study evaluates the safety and tolerability of different doses of an experimental
treatment in participants with advanced cancer.
treatment in participants with advanced cancer.
Inclusion Criteria:
- Have histological or cytological evidence of a diagnosis of cancer that is advanced
and/or metastatic for which available standard therapies have failed to provide
clinical benefit for their disease
- For Dose Escalation (Part A): cancer, either a solid tumor or a lymphoma
- For Dose Confirmation (Part B): cancer, either a solid tumor or a lymphoma
- Have the presence of measureable or non-measureable disease (Part A) or measureable
disease (Part B) as defined by the Response Evaluation Criteria in Solid Tumors or the
Revised Response Criteria for Malignant Lymphoma
- Have adequate hematologic, hepatic and renal function
- Have a performance status less than or equal to 2 on the Eastern Cooperative Oncology
Group scale
- Have discontinued all previous therapies for cancer (including chemotherapy,
radiotherapy, and immunotherapy) for at least 21 days for myelosuppressive agents or
14 days for nonmyelosuppressive agents
- Have an estimated life expectancy of greater than or equal to 12 weeks
- Are able to swallow capsules
Exclusion Criteria:
- Have an echocardiogram with clinically significant abnormalities
- For Dose Escalation (Part A): Have central nervous system malignancy or metastasis
- For Dose Confirmation (Part B): Have symptomatic central nervous system malignancy or
metastasis
- Have an acute leukemia
- Have a history of any other cancer (except non-melanoma skin cancer or carcinoma
in-situ of the cervix), unless in complete remission and stopped all therapy for that
disease for a minimum of 3 years
- Have received an autologous or allogeneic stem-cell transplant within 75 days of the
initial dose of study drug
We found this trial at
2
sites
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