The Pharmacokinetics of Azithromycin Prophylaxis for Cesarean Delivery
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 1/1/2014 |
| Start Date: | November 2011 |
| End Date: | April 2013 |
PKAZ is a single institution study designed to evaluate the optimal dosing parameters for
azithromycin for pre-surgical cesarean prophylaxis.
Hypothesis: Pre-operative administration of azithromycin results in maternal and neonatal
tissue concentrations that adequately treat microbes commonly involved in post-cesarean
infections.
azithromycin for pre-surgical cesarean prophylaxis.
Hypothesis: Pre-operative administration of azithromycin results in maternal and neonatal
tissue concentrations that adequately treat microbes commonly involved in post-cesarean
infections.
Inclusion Criteria:
- Women 19 years and older
- Term (37 weeks and greater)
- Singleton gestation
- Scheduled cesarean section
- Non-laboring
- Intact membranes
Exclusion Criteria:
- < 19 years of age
- Preterm (< 37 weeks)
- Multifetal gestation
- Laboring or ruptured membranes
- Known fetal anomaly
- Oligo- or polyhydramnios
- Macrolide allergy
- Macrolide exposure within 2 weeks
- Medical co-morbidities
- Hepatic or renal impairment
- Taking medications that prolong the QT interval
- Currently taking nelfinavir, efavirenz, or flucanozole
- Structural heart defects or arrythmia
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University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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