A Study Evaluating The Efficacy And Safety Of CP-690,550 In Patients With Moderate To Severe Ulcerative Colitis



Status:Completed
Conditions:Colitis, Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:April 2012
End Date:May 2015

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Trial Summary
Trial Overview
Inclusion Criteria

A Multicentre, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Of Oral Cp-690,550 As An Induction Therapy In Subjects With Moderate To Severe Ulcerative Colitis

This study is designed to evaluate the efficacy and safety of tofacitinib (CP-690,550) in
patients with moderate to severe ulcerative colitis who have failed or be intolerant to one
of following treatments for ulcerative colitis: oral steroids,
azathiopurine/6-mercaptopurine, or anti-TNF-alpha therapy.


Inclusion Criteria:

- Subject must be at least 18 years of age.

- Males and females with a documented diagnosis of UC at least 4 months prior to entry
into the study.

- Subjects with moderately to severely active UC based on Mayo score criteria.

- Subjects must have failed or be intolerant of at least one of the following
treatments for UC:

- Corticosteroids (oral or intravenous).

- Azathioprine or 6 mercaptopurine (6 MP).

- Anti TNF-alpha therapy.

Exclusion Criteria:

- Presence of indeterminate colitis, microscopic colitis, ischemic colitis, infectious
colitis, or clinical findings suggestive of Crohn's disease.

- Subjects with disease limited to distal 15 cm.

- Subjects without previous treatment for UC (ie, treatment naïve).

- Subjects displaying clinical signs of fulminant colitis or toxic megacolon.
We found this trial at
68
sites
St. Joseph Mercy Health System Clinical Lab
Ypsilanti, Michigan 48197
160
mi
from 43215
Ypsilanti, MI
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Cedars-Sinai Medical Center
8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
1972
mi
from 43215
Los Angeles, CA
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Gastroenterology Associates of Central Georgia
610 3rd St # 206
Macon, Georgia 31201
493
mi
from 43215
Macon, GA
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Center for Advanced Gastroenterology
260 Lookout Pl # 201
Maitland, Florida 32751
788
mi
from 43215
Maitland, FL
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Internal Medicine Specialists
Orlando, Florida 32806
796
mi
from 43215
Orlando, FL
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Shafran Gastroenterology Center
701 West Morse Boulevard
Winter Park, Florida 32789
791
mi
from 43215
Winter Park, FL
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Georgia Endoscopy Center (Colonoscopy only)
Alpharetta, Georgia 30005
412
mi
from 43215
Alpharetta, GA
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Florida Surgery Center
Altamonte Springs, Florida 32701
786
mi
from 43215
Altamonte Springs, FL
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Saint Joseph Mercy Hospital - Inpatient Pharmacy (Pharmacy Only)
Ann Arbor, Michigan 48106
164
mi
from 43215
Ann Arbor, MI
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East Ann Arbor Health and Geriatrics Center - University of Michigan Health Systems
Ann Arbor, Michigan 48109
165
mi
from 43215
Ann Arbor, MI
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University of Michigan Health Systems
Ann Arbor, Michigan 48109
165
mi
from 43215
Ann Arbor, MI
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Michigan Clinical Research Unit - Univeristy of Michigan Health System
Ann Arbor, Michigan 48109
165
mi
from 43215
Ann Arbor, MI
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Medical Science Research Building 1 - University of Michigan Health Systems
Ann Arbor, Michigan 48109
165
mi
from 43215
Ann Arbor, MI
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GI Consultants (Colonoscopy only)
Atlanta, Georgia 30342
436
mi
from 43215
Atlanta, GA
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Royal Prince Alfred Hospital
Camperdown, New South Wales 2050
9459
mi
from 43215
Camperdown,
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Clevland Clinic Department of Pharmacy
Cleveland, Ohio 44195
129
mi
from 43215
Cleveland, OH
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Nyu Langone Long Island Clinical Research Associates
Great Neck, New York 11021
492
mi
from 43215
Great Neck, NY
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NYU Langone Nassau Gastroenterology Associates
Great Neck, New York 11021
492
mi
from 43215
Great Neck, NY
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Endoscopy Center of Connecticut, LLC
Guilford, Connecticut 06437
549
mi
from 43215
Guilford, CT
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Endoscopy Center of Connecticut, LLC
Hamden, Connecticut 06518
538
mi
from 43215
Hamden, CT
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Gastroenterology Center of Connecticut
Hamden, Connecticut 06518
539
mi
from 43215
Hamden, CT
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Medical Research Center of Connecticut, LLC
Hamden, Connecticut 06518
539
mi
from 43215
Hamden, CT
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Sunrise Medical Labs
Hicksville, New York 11801
503
mi
from 43215
Hicksville, NY
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Baylor Medical Center
Houston, Texas 77030
995
mi
from 43215
Houston, TX
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Gastroenterology Consultants
Houston, Texas 77034
992
mi
from 43215
Houston, TX
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Houston Hospital for Specialized Surgery
Houston, Texas 77030
993
mi
from 43215
Houston, TX
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Baylor College of Medicine - Baylor Medical Center (Drug Storage)
Houston, Texas 77030
991
mi
from 43215
Houston, TX
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Emory Healthcare Heart Center (EKG)
Johns Creek, Georgia 30097
413
mi
from 43215
Johns Creek, GA
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Investigational Drug Pharmacy, UCSD Health System, Moores Cancer Center
La Jolla, California 92037
1954
mi
from 43215
La Jolla, CA
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UCSD Medical Center
La Jolla, California 92093
1950
mi
from 43215
La Jolla, CA
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Cedars-Sinai Medical Center - Inflammatory Bowel Disease Center
Los Angeles, California 90048
1972
mi
from 43215
Los Angeles, CA
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CRC Office - Cedars-Sinai Medical Center - Inflammatory Bowel Disease Center
Los Angeles, California 90048
1972
mi
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Los Angeles, CA
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MD Office - Cedars-Sinai Medical Center Suite 203 E
Los Angeles, California 90048
1978
mi
from 43215
Los Angeles, CA
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Regulatory Office - Cedars-Sinai Medical Center - Imflammatory Bowel Disease Center
Los Angeles, California 90048
1978
mi
from 43215
Los Angeles, CA
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Cedars Sinai Medical Center - Thalians Bldg
Los Angeles, California 90048
1978
mi
from 43215
Los Angeles, CA
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MNH Surgical Center
Maitland, Florida 32751
788
mi
from 43215
Maitland, FL
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Sand Lake Imaging
Maitland, Florida 32751
788
mi
from 43215
Maitland, FL
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Great Lakes Gastroenterology
Mentor, Ohio 44060
148
mi
from 43215
Mentor, OH
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Center for Digestive Health
Milwaukee, Wisconsin 53215
330
mi
from 43215
Milwaukee, WI
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Wisconsin Center for Advanced Research - GI Associates, LLC
Milwaukee, Wisconsin 53215
330
mi
from 43215
Milwaukee, WI
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Horizon Research Group, Inc.
Mobile, Alabama 36608
703
mi
from 43215
Mobile, AL
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Internal Medicine Center, LLC
Mobile, Alabama 36608
700
mi
from 43215
Mobile, AL
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Springhill Memorial Hospital
Mobile, Alabama 36608
700
mi
from 43215
Mobile, AL
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Kornbluth, Legnani, George MD, PC
New York, New York 10128
480
mi
from 43215
New York, NY
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Mount Sinai Doctos Faculty Practice
New York, New York 10029
481
mi
from 43215
New York, NY
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Columbia University Medical Center
630 W 168th St
New York, New York
212-305-2862
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
477
mi
from 43215
New York, NY
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Icahn School of Medicine at Mount Sinai
1428 Madison Ave
New York, New York 10029
(212) 241-6500
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
?
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New York, NY
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The Private Practice of Simon Lichtiger, MD
New York, New York 10028
480
mi
from 43215
New York, NY
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CUMC Research Pharmacy
New York, New York 10032
481
mi
from 43215
New York, NY
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Southwest Gastroenterology
Oak Lawn, Illinois 60453
275
mi
from 43215
Oak Lawn, IL
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North Florida Gastroenterology Research, LLC
Orange Park, Florida 32073
681
mi
from 43215
Orange Park, FL
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Orange Park Surgery Center
Orange Park, Florida 32073
681
mi
from 43215
Orange Park, FL
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Citrus Ambulatory Surgery Center
Orlando, Florida 32806
795
mi
from 43215
Orlando, FL
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Desert Advanced Imaging
Palm Springs, California 92262
1888
mi
from 43215
Palm Springs, CA
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Erik Palmer, DO
Palm Springs, California 92262
1888
mi
from 43215
Palm Springs, CA
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Homan A Zadeh, MD, MPH
Palm Springs, California 92262
1886
mi
from 43215
Palm Springs, CA
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Hope Square Surgical Center
Rancho Mirage, California 92270
1884
mi
from 43215
Rancho Mirage, CA
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Center for Advanced Medicine
Saint Louis, Missouri 63110
397
mi
from 43215
Saint Louis, MO
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Washington University School of Medicine - Division of Gastroenterology
Saint Louis, Missouri 63110
397
mi
from 43215
Saint Louis, MO
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Wasatch Clinical Research
Salt Lake City, Utah 84107
1514
mi
from 43215
Salt Lake City, UT
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Sharp Rees-Stealy Medical Group, Inc.
San Diego, California 92101
1951
mi
from 43215
San Diego, CA
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Sharp Rees-Stealy Medical Group, Inc.
San Diego, California 92101
1951
mi
from 43215
San Diego, CA
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Sharp Rees-Stealy
San Diego, California 92123
1951
mi
from 43215
San Diego, CA
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Atlanta Gastroenterology Specialists, PC
Suwanee, Georgia 30024
412
mi
from 43215
Suwanee, GA
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Johns Creek Diagnostic Center (X-Ray only)
Suwanee, Georgia 30024
412
mi
from 43215
Suwanee, GA
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Huron Gastroenterology Associates / Center for Digestive Care
Ypsilanti, Michigan 48197
160
mi
from 43215
Ypsilanti, MI
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Michigan Heart SJMH
Ypsilanti, Michigan 48106
164
mi
from 43215
Ypsilanti, MI
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Florida Medical Clinic
Zephyrhills, Florida 33542
812
mi
from 43215
Zephyrhills, FL
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