A Study Evaluating The Efficacy And Safety Of CP-690,550 In Patients With Moderate To Severe Ulcerative Colitis



Status:Completed
Conditions:Colitis, Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:April 2012
End Date:May 2015

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Trial Summary
Trial Overview
Inclusion Criteria

A Multicentre, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Of Oral Cp-690,550 As An Induction Therapy In Subjects With Moderate To Severe Ulcerative Colitis

This study is designed to evaluate the efficacy and safety of tofacitinib (CP-690,550) in
patients with moderate to severe ulcerative colitis who have failed or be intolerant to one
of following treatments for ulcerative colitis: oral steroids,
azathiopurine/6-mercaptopurine, or anti-TNF-alpha therapy.


Inclusion Criteria:

- Subject must be at least 18 years of age.

- Males and females with a documented diagnosis of UC at least 4 months prior to entry
into the study.

- Subjects with moderately to severely active UC based on Mayo score criteria.

- Subjects must have failed or be intolerant of at least one of the following
treatments for UC:

- Corticosteroids (oral or intravenous).

- Azathioprine or 6 mercaptopurine (6 MP).

- Anti TNF-alpha therapy.

Exclusion Criteria:

- Presence of indeterminate colitis, microscopic colitis, ischemic colitis, infectious
colitis, or clinical findings suggestive of Crohn's disease.

- Subjects with disease limited to distal 15 cm.

- Subjects without previous treatment for UC (ie, treatment naïve).

- Subjects displaying clinical signs of fulminant colitis or toxic megacolon.
We found this trial at
68
sites
Shafran Gastroenterology Center
701 West Morse Boulevard
Winter Park, Florida 32789
1110
mi
from 02139
Winter Park, FL
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Cedars-Sinai Medical Center
8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
2588
mi
from 02139
Los Angeles, CA
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Gastroenterology Associates of Central Georgia
610 3rd St # 206
Macon, Georgia 31201
948
mi
from 02139
Macon, GA
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Center for Advanced Gastroenterology
260 Lookout Pl # 201
Maitland, Florida 32751
1108
mi
from 02139
Maitland, FL
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Internal Medicine Specialists
Orlando, Florida 32806
1115
mi
from 02139
Orlando, FL
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Georgia Endoscopy Center (Colonoscopy only)
Alpharetta, Georgia 30005
915
mi
from 02139
Alpharetta, GA
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Florida Surgery Center
Altamonte Springs, Florida 32701
1106
mi
from 02139
Altamonte Springs, FL
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Saint Joseph Mercy Hospital - Inpatient Pharmacy (Pharmacy Only)
Ann Arbor, Michigan 48106
646
mi
from 02139
Ann Arbor, MI
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East Ann Arbor Health and Geriatrics Center - University of Michigan Health Systems
Ann Arbor, Michigan 48109
641
mi
from 02139
Ann Arbor, MI
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University of Michigan Health Systems
Ann Arbor, Michigan 48109
641
mi
from 02139
Ann Arbor, MI
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Michigan Clinical Research Unit - Univeristy of Michigan Health System
Ann Arbor, Michigan 48109
641
mi
from 02139
Ann Arbor, MI
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Medical Science Research Building 1 - University of Michigan Health Systems
Ann Arbor, Michigan 48109
641
mi
from 02139
Ann Arbor, MI
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GI Consultants (Colonoscopy only)
Atlanta, Georgia 30342
934
mi
from 02139
Atlanta, GA
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Royal Prince Alfred Hospital
Camperdown, New South Wales 2050
10090
mi
from 02139
Camperdown,
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Clevland Clinic Department of Pharmacy
Cleveland, Ohio 44195
543
mi
from 02139
Cleveland, OH
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Nyu Langone Long Island Clinical Research Associates
Great Neck, New York 11021
173
mi
from 02139
Great Neck, NY
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NYU Langone Nassau Gastroenterology Associates
Great Neck, New York 11021
173
mi
from 02139
Great Neck, NY
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Endoscopy Center of Connecticut, LLC
Guilford, Connecticut 06437
109
mi
from 02139
Guilford, CT
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Endoscopy Center of Connecticut, LLC
Hamden, Connecticut 06518
113
mi
from 02139
Hamden, CT
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Gastroenterology Center of Connecticut
Hamden, Connecticut 06518
114
mi
from 02139
Hamden, CT
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Medical Research Center of Connecticut, LLC
Hamden, Connecticut 06518
114
mi
from 02139
Hamden, CT
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Sunrise Medical Labs
Hicksville, New York 11801
166
mi
from 02139
Hicksville, NY
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Baylor Medical Center
Houston, Texas 77030
1605
mi
from 02139
Houston, TX
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Gastroenterology Consultants
Houston, Texas 77034
1600
mi
from 02139
Houston, TX
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Houston Hospital for Specialized Surgery
Houston, Texas 77030
1605
mi
from 02139
Houston, TX
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Baylor College of Medicine - Baylor Medical Center (Drug Storage)
Houston, Texas 77030
1601
mi
from 02139
Houston, TX
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Emory Healthcare Heart Center (EKG)
Johns Creek, Georgia 30097
911
mi
from 02139
Johns Creek, GA
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Investigational Drug Pharmacy, UCSD Health System, Moores Cancer Center
La Jolla, California 92037
2578
mi
from 02139
La Jolla, CA
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UCSD Medical Center
La Jolla, California 92093
2574
mi
from 02139
La Jolla, CA
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Cedars-Sinai Medical Center - Inflammatory Bowel Disease Center
Los Angeles, California 90048
2588
mi
from 02139
Los Angeles, CA
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CRC Office - Cedars-Sinai Medical Center - Inflammatory Bowel Disease Center
Los Angeles, California 90048
2588
mi
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Los Angeles, CA
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MD Office - Cedars-Sinai Medical Center Suite 203 E
Los Angeles, California 90048
2594
mi
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Los Angeles, CA
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Regulatory Office - Cedars-Sinai Medical Center - Imflammatory Bowel Disease Center
Los Angeles, California 90048
2594
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from 02139
Los Angeles, CA
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Cedars Sinai Medical Center - Thalians Bldg
Los Angeles, California 90048
2594
mi
from 02139
Los Angeles, CA
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MNH Surgical Center
Maitland, Florida 32751
1108
mi
from 02139
Maitland, FL
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Sand Lake Imaging
Maitland, Florida 32751
1108
mi
from 02139
Maitland, FL
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Great Lakes Gastroenterology
Mentor, Ohio 44060
526
mi
from 02139
Mentor, OH
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Center for Digestive Health
Milwaukee, Wisconsin 53215
853
mi
from 02139
Milwaukee, WI
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Wisconsin Center for Advanced Research - GI Associates, LLC
Milwaukee, Wisconsin 53215
853
mi
from 02139
Milwaukee, WI
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Horizon Research Group, Inc.
Mobile, Alabama 36608
1241
mi
from 02139
Mobile, AL
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Internal Medicine Center, LLC
Mobile, Alabama 36608
1235
mi
from 02139
Mobile, AL
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Springhill Memorial Hospital
Mobile, Alabama 36608
1235
mi
from 02139
Mobile, AL
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Kornbluth, Legnani, George MD, PC
New York, New York 10128
183
mi
from 02139
New York, NY
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Mount Sinai Doctos Faculty Practice
New York, New York 10029
182
mi
from 02139
New York, NY
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Columbia University Medical Center
630 W 168th St
New York, New York
212-305-2862
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
188
mi
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New York, NY
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Icahn School of Medicine at Mount Sinai
1428 Madison Ave
New York, New York 10029
(212) 241-6500
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
?
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New York, NY
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The Private Practice of Simon Lichtiger, MD
New York, New York 10028
183
mi
from 02139
New York, NY
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CUMC Research Pharmacy
New York, New York 10032
180
mi
from 02139
New York, NY
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Southwest Gastroenterology
Oak Lawn, Illinois 60453
854
mi
from 02139
Oak Lawn, IL
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North Florida Gastroenterology Research, LLC
Orange Park, Florida 32073
1027
mi
from 02139
Orange Park, FL
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Orange Park Surgery Center
Orange Park, Florida 32073
1027
mi
from 02139
Orange Park, FL
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Citrus Ambulatory Surgery Center
Orlando, Florida 32806
1114
mi
from 02139
Orlando, FL
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Desert Advanced Imaging
Palm Springs, California 92262
2509
mi
from 02139
Palm Springs, CA
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Erik Palmer, DO
Palm Springs, California 92262
2509
mi
from 02139
Palm Springs, CA
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Homan A Zadeh, MD, MPH
Palm Springs, California 92262
2507
mi
from 02139
Palm Springs, CA
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Hope Square Surgical Center
Rancho Mirage, California 92270
2505
mi
from 02139
Rancho Mirage, CA
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Center for Advanced Medicine
Saint Louis, Missouri 63110
1036
mi
from 02139
Saint Louis, MO
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Washington University School of Medicine - Division of Gastroenterology
Saint Louis, Missouri 63110
1036
mi
from 02139
Saint Louis, MO
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Wasatch Clinical Research
Salt Lake City, Utah 84107
2092
mi
from 02139
Salt Lake City, UT
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Sharp Rees-Stealy Medical Group, Inc.
San Diego, California 92101
2576
mi
from 02139
San Diego, CA
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Sharp Rees-Stealy Medical Group, Inc.
San Diego, California 92101
2576
mi
from 02139
San Diego, CA
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Sharp Rees-Stealy
San Diego, California 92123
2576
mi
from 02139
San Diego, CA
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Atlanta Gastroenterology Specialists, PC
Suwanee, Georgia 30024
906
mi
from 02139
Suwanee, GA
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Johns Creek Diagnostic Center (X-Ray only)
Suwanee, Georgia 30024
906
mi
from 02139
Suwanee, GA
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Huron Gastroenterology Associates / Center for Digestive Care
Ypsilanti, Michigan 48197
638
mi
from 02139
Ypsilanti, MI
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St. Joseph Mercy Health System Clinical Lab
Ypsilanti, Michigan 48197
638
mi
from 02139
Ypsilanti, MI
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Michigan Heart SJMH
Ypsilanti, Michigan 48106
646
mi
from 02139
Ypsilanti, MI
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Florida Medical Clinic
Zephyrhills, Florida 33542
1157
mi
from 02139
Zephyrhills, FL
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