A Study Evaluating The Efficacy And Safety Of CP-690,550 In Patients With Moderate To Severe Ulcerative Colitis



Status:Completed
Conditions:Colitis, Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:April 2012
End Date:May 2015

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Multicentre, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Of Oral Cp-690,550 As An Induction Therapy In Subjects With Moderate To Severe Ulcerative Colitis

This study is designed to evaluate the efficacy and safety of tofacitinib (CP-690,550) in
patients with moderate to severe ulcerative colitis who have failed or be intolerant to one
of following treatments for ulcerative colitis: oral steroids,
azathiopurine/6-mercaptopurine, or anti-TNF-alpha therapy.


Inclusion Criteria:

- Subject must be at least 18 years of age.

- Males and females with a documented diagnosis of UC at least 4 months prior to entry
into the study.

- Subjects with moderately to severely active UC based on Mayo score criteria.

- Subjects must have failed or be intolerant of at least one of the following
treatments for UC:

- Corticosteroids (oral or intravenous).

- Azathioprine or 6 mercaptopurine (6 MP).

- Anti TNF-alpha therapy.

Exclusion Criteria:

- Presence of indeterminate colitis, microscopic colitis, ischemic colitis, infectious
colitis, or clinical findings suggestive of Crohn's disease.

- Subjects with disease limited to distal 15 cm.

- Subjects without previous treatment for UC (ie, treatment naïve).

- Subjects displaying clinical signs of fulminant colitis or toxic megacolon.
We found this trial at
68
sites
Regulatory Office - Cedars-Sinai Medical Center - Imflammatory Bowel Disease Center
Los Angeles, California 90048
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Cedars-Sinai Medical Center
8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Gastroenterology Associates of Central Georgia
610 3rd St # 206
Macon, Georgia 31201
?
mi
from
Macon, GA
Click here to add this to my saved trials
Center for Advanced Gastroenterology
260 Lookout Pl # 201
Maitland, Florida 32751
?
mi
from
Maitland, FL
Click here to add this to my saved trials
Internal Medicine Specialists
Orlando, Florida 32806
?
mi
from
Orlando, FL
Click here to add this to my saved trials
Shafran Gastroenterology Center
701 West Morse Boulevard
Winter Park, Florida 32789
?
mi
from
Winter Park, FL
Click here to add this to my saved trials
Georgia Endoscopy Center (Colonoscopy only)
Alpharetta, Georgia 30005
?
mi
from
Alpharetta, GA
Click here to add this to my saved trials
Florida Surgery Center
Altamonte Springs, Florida 32701
?
mi
from
Altamonte Springs, FL
Click here to add this to my saved trials
Saint Joseph Mercy Hospital - Inpatient Pharmacy (Pharmacy Only)
Ann Arbor, Michigan 48106
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
East Ann Arbor Health and Geriatrics Center - University of Michigan Health Systems
Ann Arbor, Michigan 48109
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
University of Michigan Health Systems
Ann Arbor, Michigan 48109
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Michigan Clinical Research Unit - Univeristy of Michigan Health System
Ann Arbor, Michigan 48109
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Medical Science Research Building 1 - University of Michigan Health Systems
Ann Arbor, Michigan 48109
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
GI Consultants (Colonoscopy only)
Atlanta, Georgia 30342
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Royal Prince Alfred Hospital
Camperdown, New South Wales 2050
?
mi
from
Camperdown,
Click here to add this to my saved trials
Clevland Clinic Department of Pharmacy
Cleveland, Ohio 44195
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Nyu Langone Long Island Clinical Research Associates
Great Neck, New York 11021
?
mi
from
Great Neck, NY
Click here to add this to my saved trials
NYU Langone Nassau Gastroenterology Associates
Great Neck, New York 11021
?
mi
from
Great Neck, NY
Click here to add this to my saved trials
Endoscopy Center of Connecticut, LLC
Guilford, Connecticut 06437
?
mi
from
Guilford, CT
Click here to add this to my saved trials
Endoscopy Center of Connecticut, LLC
Hamden, Connecticut 06518
?
mi
from
Hamden, CT
Click here to add this to my saved trials
Gastroenterology Center of Connecticut
Hamden, Connecticut 06518
?
mi
from
Hamden, CT
Click here to add this to my saved trials
Medical Research Center of Connecticut, LLC
Hamden, Connecticut 06518
?
mi
from
Hamden, CT
Click here to add this to my saved trials
Sunrise Medical Labs
Hicksville, New York 11801
?
mi
from
Hicksville, NY
Click here to add this to my saved trials
Baylor Medical Center
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Gastroenterology Consultants
Houston, Texas 77034
?
mi
from
Houston, TX
Click here to add this to my saved trials
Houston Hospital for Specialized Surgery
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Baylor College of Medicine - Baylor Medical Center (Drug Storage)
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Emory Healthcare Heart Center (EKG)
Johns Creek, Georgia 30097
?
mi
from
Johns Creek, GA
Click here to add this to my saved trials
Investigational Drug Pharmacy, UCSD Health System, Moores Cancer Center
La Jolla, California 92037
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
UCSD Medical Center
La Jolla, California 92093
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
Cedars-Sinai Medical Center - Inflammatory Bowel Disease Center
Los Angeles, California 90048
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
CRC Office - Cedars-Sinai Medical Center - Inflammatory Bowel Disease Center
Los Angeles, California 90048
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
MD Office - Cedars-Sinai Medical Center Suite 203 E
Los Angeles, California 90048
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Cedars Sinai Medical Center - Thalians Bldg
Los Angeles, California 90048
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
MNH Surgical Center
Maitland, Florida 32751
?
mi
from
Maitland, FL
Click here to add this to my saved trials
Sand Lake Imaging
Maitland, Florida 32751
?
mi
from
Maitland, FL
Click here to add this to my saved trials
Great Lakes Gastroenterology
Mentor, Ohio 44060
?
mi
from
Mentor, OH
Click here to add this to my saved trials
Center for Digestive Health
Milwaukee, Wisconsin 53215
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
Wisconsin Center for Advanced Research - GI Associates, LLC
Milwaukee, Wisconsin 53215
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
Horizon Research Group, Inc.
Mobile, Alabama 36608
?
mi
from
Mobile, AL
Click here to add this to my saved trials
Internal Medicine Center, LLC
Mobile, Alabama 36608
?
mi
from
Mobile, AL
Click here to add this to my saved trials
Springhill Memorial Hospital
Mobile, Alabama 36608
?
mi
from
Mobile, AL
Click here to add this to my saved trials
Kornbluth, Legnani, George MD, PC
New York, New York 10128
?
mi
from
New York, NY
Click here to add this to my saved trials
Mount Sinai Doctos Faculty Practice
New York, New York 10029
?
mi
from
New York, NY
Click here to add this to my saved trials
Columbia University Medical Center
630 W 168th St
New York, New York
212-305-2862
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
?
mi
from
New York, NY
Click here to add this to my saved trials
Icahn School of Medicine at Mount Sinai
1428 Madison Ave
New York, New York 10029
(212) 241-6500
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
?
mi
from
New York, NY
Click here to add this to my saved trials
The Private Practice of Simon Lichtiger, MD
New York, New York 10028
?
mi
from
New York, NY
Click here to add this to my saved trials
CUMC Research Pharmacy
New York, New York 10032
?
mi
from
New York, NY
Click here to add this to my saved trials
Southwest Gastroenterology
Oak Lawn, Illinois 60453
?
mi
from
Oak Lawn, IL
Click here to add this to my saved trials
North Florida Gastroenterology Research, LLC
Orange Park, Florida 32073
?
mi
from
Orange Park, FL
Click here to add this to my saved trials
Orange Park Surgery Center
Orange Park, Florida 32073
?
mi
from
Orange Park, FL
Click here to add this to my saved trials
Citrus Ambulatory Surgery Center
Orlando, Florida 32806
?
mi
from
Orlando, FL
Click here to add this to my saved trials
Desert Advanced Imaging
Palm Springs, California 92262
?
mi
from
Palm Springs, CA
Click here to add this to my saved trials
Erik Palmer, DO
Palm Springs, California 92262
?
mi
from
Palm Springs, CA
Click here to add this to my saved trials
Homan A Zadeh, MD, MPH
Palm Springs, California 92262
?
mi
from
Palm Springs, CA
Click here to add this to my saved trials
Hope Square Surgical Center
Rancho Mirage, California 92270
?
mi
from
Rancho Mirage, CA
Click here to add this to my saved trials
Center for Advanced Medicine
Saint Louis, Missouri 63110
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Washington University School of Medicine - Division of Gastroenterology
Saint Louis, Missouri 63110
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Wasatch Clinical Research
Salt Lake City, Utah 84107
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
Sharp Rees-Stealy Medical Group, Inc.
San Diego, California 92101
?
mi
from
San Diego, CA
Click here to add this to my saved trials
Sharp Rees-Stealy Medical Group, Inc.
San Diego, California 92101
?
mi
from
San Diego, CA
Click here to add this to my saved trials
Sharp Rees-Stealy
San Diego, California 92123
?
mi
from
San Diego, CA
Click here to add this to my saved trials
Atlanta Gastroenterology Specialists, PC
Suwanee, Georgia 30024
?
mi
from
Suwanee, GA
Click here to add this to my saved trials
Johns Creek Diagnostic Center (X-Ray only)
Suwanee, Georgia 30024
?
mi
from
Suwanee, GA
Click here to add this to my saved trials
Huron Gastroenterology Associates / Center for Digestive Care
Ypsilanti, Michigan 48197
?
mi
from
Ypsilanti, MI
Click here to add this to my saved trials
St. Joseph Mercy Health System Clinical Lab
Ypsilanti, Michigan 48197
?
mi
from
Ypsilanti, MI
Click here to add this to my saved trials
Michigan Heart SJMH
Ypsilanti, Michigan 48106
?
mi
from
Ypsilanti, MI
Click here to add this to my saved trials
Florida Medical Clinic
Zephyrhills, Florida 33542
?
mi
from
Zephyrhills, FL
Click here to add this to my saved trials