The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)

Inclusion Criteria:

- Men or women 18 to 65 years of age

- Score in study range on the NEO-FFI

- No current Axis I DSM-IV excluded diagnoses as determined by the SCID completed
within the past 4 months.

- Must be able and willing to understand study procedures and return to the clinic on
two separate consecutive days for the fear-conditioning procedures.

- Subjects must be able to give informed consent and be willing and able to comply with
study procedures.

Exclusion Criteria:

- Presence of a current DSM-IV Axis I diagnosis as measured by the SCID.

- A serious medical condition or other condition deemed likely to result in surgery or
hospitalization, or which would make participation in the study difficult.

- Patients with a history of trauma resulting in head injury related seizures or with
epilepsy (except a prior history of febrile seizures of infancy which are not
exclusionary).

- Use of supplemental hormones (birth control, estrogen, testosterone, prednisone, etc)
or narcotics.

- Pregnant or lactating women.

- Women of childbearing potential not using medically accepted forms of contraception.

- Current use of the excluded psychiatric medications.

- Known hypersensitivity to oxytocin

- Known hyponatremia.