Open-Label Pilot Study of Guanfacine-Extended Release for the Treatment of Cannabis Dependence

Cannabis use disorders remain the most common illicit drug use disorder and options for
treatment remain limited. Compared to other abusable substances, there has been little
investigation of pharmacotherapies for cannabis dependence and no effective pharmacotherapy
for cannabis dependence has been developed yet. As such, the development of effective
cannabis dependence pharmacotherapy is an important unmet public health need. Lofexidine, an
alpha-2 agonist, is effective in treating opioid withdrawal and shows promise as cannabis use
disorder pharmacotherapy, though its use may be limited by a cumbersome (thrice daily) dosing
regimen. An alpha-2-agonist with a longer half-life, such as guanfacine, may have some of the
same benefits as lofexidine at comparable doses, but its easier (once daily) dosing regimen
may promote compliance and treatment retention. The purpose of this study is therefore to
determine whether guanfacine represents a tolerable, potentially effective pharmacotherapy
option for cannabis dependence. This pilot study can also provide the basis for subsequently
conducting a larger study aimed at determining efficacy with the appropriate randomized,
placebo-controlled design.

Inclusion Criteria:

- Men and women between the ages of 18-60 who meet DSM-IV criteria for current marijuana
dependence

- Individuals must report using marijuana at least 20 days in the past 30 days and have
a positive urine test for THC on the day of study entry.

- Individual must describe marijuana as their primary drug of abuse.

- Individuals must be capable of giving informed consent and capable of complying with
study procedures.

Exclusion Criteria:

- Meets DSM-IV-TR criteria for schizophrenia, schizoaffective illness, psychotic
disorder other than transient psychosis due to drug abuse, major depression, bipolar
illness or psychiatric disorders (other than substance abuse) which require
psychiatric intervention.

- Unstable medication conditions, such as poorly controlled diabetes or hypertension
(>140/90 mmHg), which might make participation hazardous.

- Individuals with liver enzyme function tests greater than three times normal, or acute
hepatitis

- Individuals with a history of a seizure disorder

- Individuals with current suicidal risk.

- Individuals who are cognitively impaired

- Bradycardia (< 50 beats/minute), hypotension (sitting or standing BP < 90/50), or
symptoms attributable to low BP (i.e. lightheadedness or dizziness on standing).

- Nursing mothers and pregnant women. Women of child bearing age will be included in the
study provided that they are not pregnant, based on the results of a blood pregnancy
test drawn at the time of screening. They must also agree to use a method of
contraception with proven efficacy and agree not to become pregnant during the study.
To confirm this, urine pregnancy tests will be repeated monthly. Women will be
provided a full explanation of the potential dangers of pregnancy while on the study
medication. If a woman becomes pregnant, the study medication will be discontinued.

- Individuals who are physiologically dependent on any other drugs (excluding nicotine)
that would require a medical intervention

- Individuals with known sensitivity to alpha-2 Agonists

- Individuals with coronary vascular disease as indicated by history or suspected by
abnormal ECG or history of cardiac symptoms

- Individuals currently being treated with antihypertensive medication, including
alpha-2 agonists

- Individuals currently taking medications that may interact adversely with guanfacine.

- Individuals who are court-mandated to treatment.