A Study of AC220 Given After Transplant in Subjects With Acute Myeloid Leukemia (AML)

This is a two-part, sequential group dose escalation study.

In Part 1, subjects will be enrolled into successive cohorts to determine the maximum
tolerated dose (MTD). Dose escalation decision will be made based on dose limiting toxicities
(DLTs) that occur in subjects treated to date at a given dose level. In Part 2, a
confirmation cohort will be opened to confirm the safety at the MTD.

Subjects who have had an allogeneic Hematopoietic Stem Cell Transplant (HSCT) will enter
treatment with AC220 between 30 to 60 days after receiving allogeneic HSCT. AC220 will be
administered every day, with 28 consecutive days defined as a treatment cycle. Subjects may
receive up to 24 continuous treatment cycles. Subjects will have study visits each week for
the first 2 cycles, and then on Day 1 of each cycle after that.

Inclusion Criteria:

- Subject has a diagnosis of acute myeloid leukemia (AML) according to WHO
classification (2008) and has received a high dose or a reduced intensity conditioning
allogeneic Hematopoietic Stem Cell Transplant (HSCT) during first or second remission
and within 30 to 60 days prior to first dose of AC220. Donors may be human leukocyte
antigen (HLA)-matched for HLA-A, B, C, DRB1, and DQB1 by high resolution typing,
related or unrelated (only a single allele disparity will be allowed for HLA-A, B, or
C as defined by high resolution typing) Note: more than one HSCT is allowed

- Subject must be in morphologic remission (< 5% marrow blasts) and without active
central nervous system (CNS) AML within 14 days prior to first dose of AC220

- Subject must have CD3 donor chimerism > 50 % at Screening

- Subject has a Karnofsky Performance Status (KPS) of ≥ 60

- Subject must have absolute neutrophil count (ANC) > 1000/mm3 and platelet count >
50,000/mm3 without platelet transfusion support within 2 weeks prior to first dose

- Subject must have adequate renal, hepatic, and coagulation parameters

- Female subjects must not be lactating and must not be breastfeeding at Screening or
during the study period and for 28 days [or five half lives of the study drug
whichever is longer] after final study drug administration.

- Subject is able to comply with study procedures and follow-up examinations

Exclusion Criteria:

- Subject received AC220 and relapsed during treatment with AC220

- Subject has active ≥ Grade 2 graft versus host disease (GVHD)

- Subject has received concurrent chemotherapy, immunotherapy, or radio-therapy within
21 days prior to the first dose of AC220, or any antineoplastic therapy that is
considered to be investigational (i.e., used for non-approved indications(s) and in
the context of a research investigation) within 30 days or 5 half-lives (whichever is
longer) prior to the first dose of study drug

- Subject requires treatment with concomitant drugs that prolong QT/QTc interval or
strong cytochrome P-3A4 (CYP3A4) inhibitors or inducers with the exception of
immunosuppressants, antibiotics, antifungals, and antivirals that are used as standard
of care post-transplant or to prevent or treat infections and other such drugs that
are considered absolutely essential for the care of the subject

- Subject requires treatment with anticoagulant therapy

- Subject has a known positive test for human immunodeficiency virus, hepatitis C, or
hepatitis B surface antigen

- Subject had major surgery within 4 weeks prior to first dose of AC220

- Subject has uncontrolled or significant cardiovascular disease

- Subject has an active acute fungal, bacterial, or other infection that is unresponsive
to therapy

- Subject has participated in any interventional clinical study or has been treated with
any investigational drugs within 30 days or 5 half lives whichever is longer, prior to
the initiation of Screening.

- Subject has any medical, psychiatric, addictive or other kind of disorder which
compromises the ability of the subject to give written informed consent and/or to
comply with procedures