Drug Interaction Study of Clopidogrel and Rosuvastatin

Inclusion Criteria:

- Healthy individuals, male or female, age 18-65 years old, with no current medical
conditions or active diagnoses as determined by the study doctor based on history,
physical exam and laboratory evaluations

- Subjects that take no other medications 2 weeks prior to the study and during the
time course of the study including prescription medications, over-the-counter
medications (except acetaminophen), dietary supplements, or drugs of abuse

- Subjects with a SLCO1B1*1A genotype

- Subjects able to maintain adequate birth control during the study independent of
hormonal contraceptive use

- Subjects able to abstain from grapefruit, grapefruit juice, orange juice, caffeinated
beverages and/or alcoholic beverages from 3 pm the day before the study to completion
of that study day.

- Participants determined to have normal liver and kidney function as measured at
baseline

- BMI between 18.5 - 30 kg/m2

- Subjects capable of fasting from food and beverages at least 8 hours prior to
medication dosing

- Be able to read, speak, and understand English

Exclusion Criteria:

- Subjects with active medical problems

- Subjects on chronic prescription or OTC medications that cannot be stopped 2 weeks
prior to and during the study.

- Subjects incapable of multiple blood draws (HCT <30 mg/dL)

- Subjects with a history of rhabdomyolysis

- Subjects with a history of drug-related myalgias

- Subjects with a history or diagnosis of hemorrhagic tendencies or blood dyscrasias

- Subjects with a history of GI bleed or peptic ulcer disease

- Subjects with a recent history of trauma

- Subjects with a recent history of or upcoming plan of surgery

- Subjects that smoke tobacco or have ongoing alcohol or illegal drug use

- Subjects who are pregnant, lactating, or trying to conceive during the study period

- Subjects allergic to rosuvastatin or clopidogrel or any known component of the
medications