Event Related Potentials in Borderline Personality Disorder and Major Depression
| Status: | Completed |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD), Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 4/2/2016 |
| Start Date: | July 2011 |
| End Date: | March 2013 |
| Contact: | Amruthur G Ramamurthy, MD |
| Email: | ramamurg@upstate.edu |
| Phone: | 315 464 5668 |
This study examines whether depression in people with borderline personality disorder is
different than depression in people without borderline personality disorder.
Unlike people who have depression alone (i.e. without borderline personality disorder),
people with borderline personality disorder have depressions that often do not improve with
medications. This makes treating depression much more challenging in someone with borderline
personality disorder than without borderline personality disorder.
Borderline personality disorderis associated with difficulty in understanding and
communicating feelings. Impaired emotion processing may reflect dysfunction of an area of
the brain, the anterior cingulate.
Depression is associated with changes in anterior cingulate activity. The investigators
believe that when borderline personality disorder is present with depression, brain activity
changes in the anterior cingulate will not be the same as in depressed patients without
borderline personality disorder.
An electroencephalogram records brain electrical activity. In this study, the investigators
will measure electroencephalogram indices reflecting anterior cingulate activity.
HYPOTHESIS: In this study, the investigators predict that when borderline personality is
present with depression, electroencephalogram indices of anterior cingulate activity will be
different from when depression is present alone (without borderline personality). This could
help to explain why people with borderline personality have depressions that are harder to
treat than depressions in people without borderline personality.
The investigators also predict that electroencephalogram indices of the anterior cingulate
will reflect emotional processing ability, as measured by validated questionnaires.
different than depression in people without borderline personality disorder.
Unlike people who have depression alone (i.e. without borderline personality disorder),
people with borderline personality disorder have depressions that often do not improve with
medications. This makes treating depression much more challenging in someone with borderline
personality disorder than without borderline personality disorder.
Borderline personality disorderis associated with difficulty in understanding and
communicating feelings. Impaired emotion processing may reflect dysfunction of an area of
the brain, the anterior cingulate.
Depression is associated with changes in anterior cingulate activity. The investigators
believe that when borderline personality disorder is present with depression, brain activity
changes in the anterior cingulate will not be the same as in depressed patients without
borderline personality disorder.
An electroencephalogram records brain electrical activity. In this study, the investigators
will measure electroencephalogram indices reflecting anterior cingulate activity.
HYPOTHESIS: In this study, the investigators predict that when borderline personality is
present with depression, electroencephalogram indices of anterior cingulate activity will be
different from when depression is present alone (without borderline personality). This could
help to explain why people with borderline personality have depressions that are harder to
treat than depressions in people without borderline personality.
The investigators also predict that electroencephalogram indices of the anterior cingulate
will reflect emotional processing ability, as measured by validated questionnaires.
Inclusion Criteria:
- age between 18 and 45
- female
- noncontrols diagnosis: major depression &/or borderline personality disorder
- Control participants should have neither major depression or borderline pers.
- meet Structured Controlled Interview for DSM - II cut off scores
- meet Beck Depression Inventory (BDI)cut off scores
- meet Borderline Evaluation of Severity Over Time(BEST) cut off scores.
Exclusion Criteria:
- based on having none of the below diagnoses from patient history, prior clinical
records and based on MINI Plus International Neuropsychiatry Interview
- schizophrenia
- psychosis
- Attention Deficit Hyperactivity Disorder
- Obsessive Compulsive Disorder
- bipolar disorder
- mental retardation
- dementia
- CNS disease
- Post-Traumatic Stress Disorder in non-borderline personality disorder groups
- Recreational drug or alcohol use in the past week.
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