Extubation Readiness Study in Very Low Birthweight Infants
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital, Women's Studies, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Other, Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2011 |
| Contact: | Annie Giaccone, MD |
| Email: | giacconea@email.chop.edu |
| Phone: | 215-590-1653 |
A Randomized Trial of the Spontaneous Breathing Trial to Extubate Very Low Birthweight Infants
The objective of this study is to determine whether use of the spontaneous breathing trial
allows for earlier successful extubation of very low birth weight (VLBW) infants who are
intubated for >48 hours and have not yet been successfully extubated (extubated >7 days).
allows for earlier successful extubation of very low birth weight (VLBW) infants who are
intubated for >48 hours and have not yet been successfully extubated (extubated >7 days).
Inclusion Criteria:
- Birthweight >500g and<1500g.
- Postmenstrual age <34 weeks
- Mechanically ventilated >48 hours
- Never successfully extubated
Exclusion Criteria:
- Congenital heart disease (other than patent ductus arteriosus (PDA), patent foramen
ovale (PFO), and restrictive ventricular septal defect (VSD)
- Known or suspected airway anomalies
- Severe congenital malformations
- Need to remain intubated for other reasons (i.e. having surgery)
- Has met SBT criteria on previous calendar day (after 48 hrs of ventilation, PIP≤18,
PEEP≤6, FiO2≤40%, Rate≤30, PS≤8)
We found this trial at
2
sites
Phialdelphia, Pennsylvania 19104
Principal Investigator: Ann-Johanna Giaccone, MD
Phone: 215-590-1653
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800 Spruce St
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
215-829-3000
Principal Investigator: Soraya Abbasi, MD
Pennsylvania Hospital Pennsylvania Hospital, the nation's first hospital, has been a leader in patient care,...
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