Ventricular Tachyarrhythmia (VT) Storm, Gene Expression in Implantable Cardioverter Defibrillator (ICD) Patients With Electrical Storm
| Status: | Completed |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/14/2019 |
| Start Date: | August 26, 2008 |
| End Date: | December 2018 |
Gene Expression in ICD Patients With Electrical Storm
The purpose of the proposed pilot study is to identify factors which are associated with
periods of high ventricular arrhythmia burden. This will be performed by analysis of gene
expression from peripheral blood samples.
periods of high ventricular arrhythmia burden. This will be performed by analysis of gene
expression from peripheral blood samples.
This is a study of patients with ICD implants who present with multiple(>2), low-level(1-2)
or inappropriate therapies to their defibrillator. The purpose of this pilot study is to
identify factors which are associated with periods of high ventricular arrhythmia burden by
looking at gene expression from peripheral blood, in addition to levels of known markers of
CHF, including catecholamine levels, B-type natriuretic peptide, and troponin. This study
hypothesizes that extrinsic or systemic factors play a role in triggering these events, and
if true should yield candidate proteins which would spawn functional studies to prove a role
in causation. Additionally, identification of a marker of increased recurrence of events may
aid in guiding therapy (starting an anti-arrhythmic versus awaiting the next event).
or inappropriate therapies to their defibrillator. The purpose of this pilot study is to
identify factors which are associated with periods of high ventricular arrhythmia burden by
looking at gene expression from peripheral blood, in addition to levels of known markers of
CHF, including catecholamine levels, B-type natriuretic peptide, and troponin. This study
hypothesizes that extrinsic or systemic factors play a role in triggering these events, and
if true should yield candidate proteins which would spawn functional studies to prove a role
in causation. Additionally, identification of a marker of increased recurrence of events may
aid in guiding therapy (starting an anti-arrhythmic versus awaiting the next event).
Inclusion Criteria:
- ICD patients at least 18 years of age that present within a 72 hour period: 1) > 2
therapies for ventricular arrhythmias; 2) 1-2 therapies for ventricular arrhythmias;
3) inappropriate therapies for ventricular arrhythmias
- Able to give informed consent
Exclusion Criteria:
- Inability to give informed consent
We found this trial at
2
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