Changes in Brain Structure Related to Systemic Chemotherapy Treatment: A Prospective Study in Individuals Diagnosed With Non-small Cell Lung Cancer Utilizing High-resolution Structural Magnetic Resonance Imaging
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 1/1/2014 |
| Start Date: | November 2011 |
| End Date: | November 2014 |
| Contact: | James C Root, Ph.D. |
| Phone: | 646-888-0035 |
The purpose of this study is to learn about the effects of cancer treatment on the brain.
Some cancer patients report changes in their memory or thinking after treatment. These
changes could be a result of changes in brain structure, such as a change in size or
thickness of different parts of the brain. The investigators will look to see if these
changes in brain structure happen through the results of magnetic resonance imaging (MRI).
The investigators will do this by looking at the brain structure of lung cancer patients who
have surgery and chemotherapy versus those who have surgery only.
Some cancer patients report changes in their memory or thinking after treatment. These
changes could be a result of changes in brain structure, such as a change in size or
thickness of different parts of the brain. The investigators will look to see if these
changes in brain structure happen through the results of magnetic resonance imaging (MRI).
The investigators will do this by looking at the brain structure of lung cancer patients who
have surgery and chemotherapy versus those who have surgery only.
Inclusion Criteria:
- Patients between the ages of 18 and 80 years old
- As per self report and/or medical record female patients are either postmenopausal or
not able to become pregnant
- Patients with biopsy proven or suspected non-small cell lung cancer planned to
undergo induction chemotherapy and surgery, OR with biopsy proven or suspected
non-small cell lung cancer planned to undergo immediate surgical resection
- No clinical/neurological symptoms suggestive of brain metastases by attending's
judgment as documented in the medical record and/or correspondence with the research
team
- In the judgement of the consenting professional, patient is able to understand
English, through verbal and written communication
- Patient is able to undergo MRI scanning (verified with pre-MRI Safety Screening form
(Appendix A) used in MSKCC MRI Centers) completed at screening and again prior to
having the MRI.
Exclusion Criteria:
- Patients with history of significant neurological diagnoses including stroke, tumor,
dementia, epilepsy, or multiple sclerosis as indicated by medical records and/or self
report
- History of head injury with evidence of brain injury or loss of consciousness for >
60 minutes as per EMR or self-report
- No prior treatment with chemotherapy
- Participant has dentures, body jewelry or wig that they are unable to remove as per
self-report
- Patient reports that he/she cannot undergo MRI scanning without significant distress
or discomfort
- Significant psychiatric or cognitive disturbance sufficient, in the investigator's
judgment, to preclude providing informed consent or participating in the study (i.e.,
schizophrenia).
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