Insulin Resistance Before and During Pregnancy in Women With Polycystic Ovary Syndrome
| Status: | Terminated |
|---|---|
| Conditions: | Ovarian Cancer, Obesity Weight Loss, Women's Studies, Endocrine |
| Therapuetic Areas: | Endocrinology, Oncology, Reproductive |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 4/21/2016 |
| Start Date: | May 2013 |
| End Date: | August 2014 |
Insulin Resistance Before and During Pregnancy in Women With PCOS
The polycystic ovary syndrome (PCOS) affects about 10% of reproductive-age women. Women with
PCOS are at a higher risk of gestational diabetes, which may lead to more pregnancy
complications. It is unknown if there are factors that may predict which women are more at
risk.
The goal of this study is to evaluate the risk factors of gestational diabetes, such as
dietary and physical activity factors, race, and how the body handles its own hormones
during pregnancy. Our long term goal is to contribute in finding ways to successfully
prevent gestational diabetes.
PCOS are at a higher risk of gestational diabetes, which may lead to more pregnancy
complications. It is unknown if there are factors that may predict which women are more at
risk.
The goal of this study is to evaluate the risk factors of gestational diabetes, such as
dietary and physical activity factors, race, and how the body handles its own hormones
during pregnancy. Our long term goal is to contribute in finding ways to successfully
prevent gestational diabetes.
The polycystic ovary syndrome is the leading cause of female infertility in the United
States. The disorder affects approximately 6-10% of women of reproductive age. Insulin is a
hormone that helps the body to take up sugar from the bloodstream. It is widely accepted
that "insulin resistance" may be responsible for the polycystic ovary syndrome. Women are
insulin resistant when their bodies do not respond to insulin's action to handle sugar as
they normally should. Because of this insulin resistance, when women with the polycystic
ovary syndrome become pregnant, they are at a higher risk of developing gestational
diabetes. Gestational diabetes carries risk to both the mother and the baby. The purpose of
this study is to determine whether certain factors in women with the polycystic ovary
syndrome are linked to risk of gestational diabetes. We propose to look at demographic
factors, as well as the body's handling of estrogen (a female hormone present in high
quantities during pregnancy) in this study.
States. The disorder affects approximately 6-10% of women of reproductive age. Insulin is a
hormone that helps the body to take up sugar from the bloodstream. It is widely accepted
that "insulin resistance" may be responsible for the polycystic ovary syndrome. Women are
insulin resistant when their bodies do not respond to insulin's action to handle sugar as
they normally should. Because of this insulin resistance, when women with the polycystic
ovary syndrome become pregnant, they are at a higher risk of developing gestational
diabetes. Gestational diabetes carries risk to both the mother and the baby. The purpose of
this study is to determine whether certain factors in women with the polycystic ovary
syndrome are linked to risk of gestational diabetes. We propose to look at demographic
factors, as well as the body's handling of estrogen (a female hormone present in high
quantities during pregnancy) in this study.
Inclusion Criteria:
- Diagnosis of PCOS prior to pregnancy
- 18-40 years of age
- Documented BMI 30-40 kg/m2 (within 3 months prior to pregnancy or within 8 weeks of
gestation)
- Either of Caucasian or African-American decent by self report.
- Pregnant or attempting pregnancy
Exclusion Criteria:
- Preexisting Diabetes (impaired glucose tolerance will not be an exclusion criterion
because of the high prevalence of impaired glucose tolerance in the PCOS population).
- Hemoglobin < 8 or hemoglobin <10 with symptoms of anemia.
- Use of tobacco, alcohol or illicit substances.
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Virginia Commonwealth University Medical Center The Virginia Commonwealth University Health System is an urban, comprehensive...
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