Radiolabeled Monoclonal Antibody Therapy and Combination Chemotherapy Before Stem Cell Transplant in Treating Patients With Primary Refractory or Relapsed Hodgkin Lymphoma

PRIMARY OBJECTIVES:

I. To determine the safety and feasibility of the autologous hematopoietic cell
transplantation (AHCT) regimen of yttrium Y-90 basiliximab/DOTA, given in combination with
standard dose(s) of BEAM in patients with primary progressive or relapsed Hodgkin lymphoma
(HL).

II. To determine the recommended phase II dose (RP2D) and characterize toxicities at each
dose level - including time course.

III. To evaluate hematological recovery in terms of neutrophil and platelet engraftment time.

IV. To estimate overall response rate (ORR: complete remission [CR] + partial remission
[PR]), response duration, overall survival, progression-free survival, and the cumulative
incidence of non-relapse mortality and relapse/progression.

V. To estimate the radiation doses to the whole body and normal organs through serial imaging
studies.

VI. To define biodistribution/extended pharmacokinetics of 111indium (In)-basiliximab/DOTA
and 90Y- basiliximab/DOTA including terminal elimination, serum half-life (t1/2), and area
under the curve (AUC).

OUTLINE: DOSIMETRY STUDY: Patients receive basiliximab intravenously (IV) and indium In 111
basiliximab IV on day -21. Patients undergo indium In 111 imaging scans daily. Patients with
appropriate biodistribution continue on to treatment.

TREATMENT: Patients receive basiliximab IV and yttrium Y 90 basiliximab IV on day -14.
Patients also receive BEAM chemotherapy comprising carmustine IV over 2 hours on days -7 and
-6, etoposide IV over 4 hours twice daily (BID) and cytarabine IV over 2 hours BID on days -5
to -2, and melphalan IV on day -1. Patients undergo autologous hematopoietic progenitor cell
infusion on day 0.

After completion of study treatment, patients are followed up at day 90-100, 180, 1 year, 1.5
years, and 2-5 years.

Inclusion Criteria:

- Pathology confirmation of HL with City of Hope (COH) pathology review

- Hodgkin lymphoma that is:

- PIF (primary induction failure): did not enter complete remission with first line
of therapy; Note: a patient with PIF who responds to salvage therapy with a PR or
CR is also eligible (and would be considered PIF-sensitive)

- Early 1st relapse: initial CR of > 3 months and < 12 months after 1st line
chemotherapy

- 1st relapsed HL in a patient who is not in CR after 2 cycles of salvage therapy

- In 2nd or subsequent relapse (RL) whether in CR or not after salvage therapy

- Relapse/persistent disease evidenced by a computed tomography and fluorodeoxyglucose
(FDG)-positron emission tomography (PET), or bone marrow biopsy

- Cardiac ejection fraction of >= 50% by echocardiogram or multi gated acquisition scan
(MUGA)

- Forced expiratory volume in one second (FEV1) > 65% of predicted measured, or
diffusion capacity of the lung for carbon monoxide (DLCO) >= 50% of predicted measured

- Bilirubin =< 1.5 x normal

- Serum glutamic oxaloacetic transaminase (SGOT) or serum glutamate pyruvate
transaminase (SGPT) =< 2 x normal except in cases where abnormal liver function tests
(LFTS) are due to involvement with HL

- Serum creatinine of =< 1.5 mg/dL, and a measured creatinine clearance of >= 60 mL/min

- Karnofsky status >= 70%

- Life expectancy >= 6 months

- Females must not be pregnant or breast feeding, and must use accepted birth control
methods; males must use accepted birth control methods

- Capability of providing informed consent

- Patients will be enrolled after receiving at least two cycles of salvage cytoreductive
chemotherapy and collection of at least 3.0 x 10^6 CD34 cells/kg of autologous
hematopoietic progenitor cells (HPC-A) by apheresis; a minimum of 2 collection
procedures is required, unless collection on day #1 > 5.0 x 10^6 CD34 cells/kg; a
maximum of 10 collections is allowed; bone marrow harvest to supplement apheresis is
not allowed

- Co-enrollment on Institutional Review Board (IRB) #98117, entitled Molecular
Pathogenesis of Therapy-Related Leukemia

- All pre-study and follow-up imaging studies preferably performed at City of Hope

- Recovery from non-hematologic toxicities of salvage cytoreductive chemotherapy to =<
grade 2 (Common Terminology Criteria for Adverse Events version 4 [CTCAE v4])

- Body mass index (BMI) > 30% will be considered on a case-by-case basis by the
radiation oncology principal investigator (PI)

- While on this study, patients may not be treated with any other investigational agent
for any purpose until relapse or progression

Exclusion Criteria:

- Lymphocyte-predominant Hodgkin lymphoma

- Prior high dose chemotherapy with autologous stem cell transplant, or prior allogeneic
transplantation

- Significant prior external beam dose-limiting radiation to a critical organ based on
review of the prior radiation treatment records by the radiation oncology PI; patients
who have had prior external beam radiation > 2000 cGy (at 180 to 200 cGy per day) to
any portion of the lung will be ineligible; patients with ANY prior radiation to the
heart are ineligible; patients with > 500 cGy to any portion of the kidney will be
excluded from the study

- Presence of antibody against basiliximab (only required for patients who have received
prior antibody)

- Myelodysplasia or any active malignancy other than HL, or < 5 years remission from any
other prior malignancy, except adequately treated basal cell or squamous cell
carcinoma

- Active hepatitis B or C viral infection or hepatitis B surface antigen positive

- Positive human immunodeficiency virus antibody

- Patients with psychosocial circumstances or illnesses that preclude protocol
participation (to be determined by PI)

- Co-morbid illnesses that preclude protocol participation (to be determined by PI)

- Any cytogenetic abnormality in the bone marrow that is known to be associated with or
predictive of myelodysplasia is excluded. This includes, but is not limited to,
del(5), del(7), del(11)

- Persistent marrow involvement (> 10%) with HL after salvage cytoreductive therapy and
before stem cell mobilization

- Systemic chemotherapy or radiation within 4 weeks prior to the Y-90 dose of
radioimmunotherapy (RIT), with the exception of single agent Cytoxan priming
chemotherapy administered for mobilization

- Bone marrow (BM) harvest required to reach adequate cell dose for transplant